RT Journal Article
T1 Donor CTLA-4 Genotype Modulates the Immune Response to Minor Histocompatibility Antigen Mismatches.
A1 Gallardo, David
A1 Bosch-Vizcaya, Anna
A1 Rodriguez-Romanos, Rocio
A1 Santos, Nazly
A1 Buño, Ismael
A1 de-la-Camara, Rafael
A1 Brunet, Salut
A1 Jimenez-Velasco, Antonio
A1 Gonzalez, Marcos
A1 Nieto, Jose B
A1 Martínez-Laperche, Carolina
A1 Vallejo, Carlos
A1 Ferra, Christelle
A1 Sampol, Antònia
A1 Lopez-Jimenez, Javier
A1 Perez-Simon, Jose A
A1 Martinez, Carmen
A1 Diez, Jose L
K1 Allogeneic transplantation
K1 CTLA-4
K1 Graft-versus-host disease
K1 Minor histocompatibility antigens
AB Minor histocompatibility antigen (miHA) mismatches have been related to graft-versus-host disease (GVHD) after allogeneic stem cell transplantation, but this association remains controversial due to the lack of consistency in the results obtained by different groups. The CTLA-4 genotype of the donor has been reported to be relevant in the appearance of acute GVHD. We explored the effect of the donor's CTLA-4 genotype in the incidence of acute GVHD associated with HA-1, HA-8, or H-Y miHA mismatches in a large cohort of 1295 patients receiving an allogeneic transplant from an HLA-identical sibling donor. The incidence of acute GVHD was higher if the donor and recipient were mismatched for HA-1, HA-8, or H-Y, but only when the donor had the CTLA-4 rs231775 AA genotype (hazard ratio [HR], 2.18; 95% confidence interval [CI], 1.27 to 3.75; P = .005; HR, 2.11, 95% CI, 1.06 to 4.18; P = .033; and HR, 1.50; 95% CI, 1.05 to 2.15; P = .025, respectively). In contrast, this increased risk of developing acute GVHD was not found when the donor presented the CTLA-4 rs231775 AG or GG genotypes. We conclude that the immune response to specific miHA mismatches is modulated by the CTLA-4 genotype of the donor.
PB Elsevier
YR 2017
FD 2017-08-04
LK http://hdl.handle.net/10668/11524
UL http://hdl.handle.net/10668/11524
LA en
NO Gallardo D, Bosch-Vizcaya A, Rodríguez-Romanos R, Santos N, Buño I, de la Cámara R, et al. Donor CTLA-4 Genotype Modulates the Immune Response to Minor Histocompatibility Antigen Mismatches. Biol Blood Marrow Transplant. 2017 Dec;23(12):2042-2047
DS RISalud
RD Apr 7, 2025