%0 Journal Article
%A Gallardo, David
%A Bosch-Vizcaya, Anna
%A Rodriguez-Romanos, Rocio
%A Santos, Nazly
%A Buño, Ismael
%A de-la-Camara, Rafael
%A Brunet, Salut
%A Jimenez-Velasco, Antonio
%A Gonzalez, Marcos
%A Nieto, Jose B
%A Martínez-Laperche, Carolina
%A Vallejo, Carlos
%A Ferra, Christelle
%A Sampol, Antònia
%A Lopez-Jimenez, Javier
%A Perez-Simon, Jose A
%A Martinez, Carmen
%A Diez, Jose L
%T Donor CTLA-4 Genotype Modulates the Immune Response to Minor Histocompatibility Antigen Mismatches.
%D 2017
%U http://hdl.handle.net/10668/11524
%X Minor histocompatibility antigen (miHA) mismatches have been related to graft-versus-host disease (GVHD) after allogeneic stem cell transplantation, but this association remains controversial due to the lack of consistency in the results obtained by different groups. The CTLA-4 genotype of the donor has been reported to be relevant in the appearance of acute GVHD. We explored the effect of the donor's CTLA-4 genotype in the incidence of acute GVHD associated with HA-1, HA-8, or H-Y miHA mismatches in a large cohort of 1295 patients receiving an allogeneic transplant from an HLA-identical sibling donor. The incidence of acute GVHD was higher if the donor and recipient were mismatched for HA-1, HA-8, or H-Y, but only when the donor had the CTLA-4 rs231775 AA genotype (hazard ratio [HR], 2.18; 95% confidence interval [CI], 1.27 to 3.75; P = .005; HR, 2.11, 95% CI, 1.06 to 4.18; P = .033; and HR, 1.50; 95% CI, 1.05 to 2.15; P = .025, respectively). In contrast, this increased risk of developing acute GVHD was not found when the donor presented the CTLA-4 rs231775 AG or GG genotypes. We conclude that the immune response to specific miHA mismatches is modulated by the CTLA-4 genotype of the donor.
%K Allogeneic transplantation
%K CTLA-4
%K Graft-versus-host disease
%K Minor histocompatibility antigens
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