RT Journal Article
T1 Nosocomial meningitis caused by ESBL- and OXA-48-producing Klebsiella pneumoniae and treated with ceftazidime-avibactam. Report of one case and review of the literature.
A1 Valiente-De-Santis, L B
A1 Marquez-Gomez, I
A1 Sobrino-Diaz, B
A1 Perez-Camacho, I
A1 Mediavilla-Gradolph, C
A1 Caballero-Martinez, L F
A1 Vicente-Hernandez, F J
A1 Castelo-Corral, L
A1 Delgado-Fernandez, M
A1 Plata-Ciezar, A
A1 Ruiz-Mesa, J D
A1 Reguera-Iglesias, J M
K1 OXA-48
K1 Postsurgical meningitis
K1 Carbapenemase-producing Klebsiella pneumoniae
K1 Ceftazidime-avibactam
K1 Nosocomial meningitis
AB The infections caused by carbapenemase-producing Klebsiella pneumoniae (CPKP) have limited treatment options, [13]; this implies an even worse problem if the infection is located in the central nervous system (CNS), due to the limited blood-brain barrier (BBB) penetration of the antibiotics and, therefore, the need for higher doses. There is scarce evidence regarding the optimal dose and the cerebrospinal fluid (CSF) concentration of most new antibiotics used for the treatment of CPKP, including OXA-48-producing K. pneumoniae. CAZ-AVI is a new beta-lactam combined with extended-spectrum beta-lactamase (ESBL) inhibitor against Gram-negative bacilli (GNB), both fermenters and non-fermenters [2,4], whose action spectrum include Ambler class A (KPC), class D (OXA-48), and many class C (Amp-C) CPKP [5-9]. Thus, it constitutes the first therapeutic option in CPKP-triggered infections that are not located in the urinary tract [10].
PB Sociedad Española de Quimioterapia
YR 2022
FD 2022-10-03
LK http://hdl.handle.net/10668/21823
UL http://hdl.handle.net/10668/21823
LA en
NO Valiente De Santis LB, Márquez Gómez I, Sobrino Díaz B, Pérez Camacho I, Mediavilla Gradolph C, Caballero Martínez LF, et al. Nosocomial meningitis caused by ESBL- and OXA-48-producing Klebsiella pneumoniae and treated with ceftazidime-avibactam. Report of one case and review of the literature. Rev Esp Quimioter. 2022 Dec;35(6):572-576
DS RISalud
RD Jul 4, 2025