RT Journal Article
T1 Circulating Sex Hormone Levels and Colon Cancer Risk in Men: A Nested Case-Control Study and Meta-Analysis.
A1 Harbs, Justin
A1 Rinaldi, Sabina
A1 Gicquiau, Audrey
A1 Keski-Rahkonen, Pekka
A1 Mori, Nagisa
A1 Liu, Xijia
A1 Kaaks, Rudolf
A1 Katzke, Verena
A1 Schulze, Matthias B
A1 Agnoli, Claudia
A1 Tumino, Rosario
A1 Bueno-de-Mesquita, Bas
A1 Crous-Bou, Marta
A1 Sanchez-Perez, Maria-Jose
A1 Aizpurua, Amaia
A1 Chirlaque, María-Dolores
A1 Gurrea, Aurelio Barricarte
A1 Travis, Ruth C
A1 Watts, Eleanor L
A1 Christakoudi, Sofia
A1 Tsilidis, Konstantinos K
A1 Weiderpass, Elisabete
A1 Gunter, Marc J
A1 Van Guelpen, Bethany
A1 Murphy, Neil
A1 Harlid, Sophia
AB Endogenous sex hormones may contribute to higher colorectal cancer incidence rates in men compared with women, but despite an increased number of studies, clear evidence is lacking. We conducted a comprehensive nested case-control study of circulating concentrations of sex hormones, sex hormone precursors, and sex hormone binding globulin (SHBG) in relation to subsequent colon cancer risk in European men. Concentrations were measured using liquid LC/MS-MS in prospectively collected plasma samples from 690 cases and 690 matched controls from the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Northern Sweden Health and Disease Study (NSHDS) cohorts. Multivariable conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). In addition, we conducted a meta-analysis of previous studies on men. Circulating levels of testosterone (OR, 0.68; 95% CI, 0.51-0.89) and SHBG (OR, 0.77; 95% CI, 0.62-0.96) were inversely associated with colon cancer risk. For free testosterone, there was a nonsignificant inverse association (OR, 0.83; 95% CI, 0.58-1.18). In a dose-response meta-analysis of endogenous sex hormone levels, inverse associations with colorectal/colon cancer risk were found for testosterone [relative risks (RR) per 100 ng/dL = 0.98; 95% CI, 0.96-1.00; I2 = 22%] and free testosterone (RR per 1 ng/dL = 0.98; 95% CI, 0.95-1.00; I2 = 0%). Our results provide suggestive evidence for the association between testosterone, SHBG, and male colon cancer development. Additional support for the involvement of sex hormones in male colon cancer.
YR 2022
FD 2022
LK http://hdl.handle.net/10668/20181
UL http://hdl.handle.net/10668/20181
LA en
DS RISalud
RD Apr 20, 2025