RT Generic
T1 Emerging Roles of Epigenetics in the Control of Reproductive Function: Focus on Central Neuroendocrine Mechanisms
A1 Jesus Vazquez, Maria
A1 Daza-Duenas, Silvia
A1 Tena-Sempere, Manuel
K1 epigenetics
K1 puberty
K1 reproduction
K1 Kiss1
K1 kisspeptins
K1 GnRH
K1 nutrition
K1 environmental cues
K1 Genome-wide association
K1 Polycystic-ovary-syndrome
K1 Dna methylation
K1 Hypogonadotropic hypogonadism
K1 Metabolic-control
K1 Gene-expression
K1 Bisphenol-a
K1 Puberty
K1 Mice
K1 Age
AB Reproduction is an essential function for perpetuation of the species. As such, it is controlled by sophisticated regulatory mechanisms that allow a perfect match between environmental conditions and internal cues to ensure adequate pubertal maturation and achievement of reproductive capacity. Besides classical genetic regulatory events, mounting evidence has documented that different epigenetic mechanisms operate at different levels of the reproductive axis to finely tune the development and function of this complex neuroendocrine system along the lifespan. In this mini-review, we summarize recent evidence on the role of epigenetics in the control of reproduction, with special focus on the modulation of the central components of this axis. Particular attention will be paid to the epigenetic control of puberty and Kiss1 neurons because major developments have taken place in this domain recently. In addition, the putative role of central epigenetic mechanisms in mediating the influence of nutritional and environmental cues on reproductive function will be discussed.
PB Endocrine soc
YR 2021
FD 2021-09-27
LK https://hdl.handle.net/10668/25603
UL https://hdl.handle.net/10668/25603
LA en
DS RISalud
RD Apr 6, 2025