RT Journal Article
T1 Family history of first degree as a risk factor for colorectal cancer
A1 Rubin-Garcia, Maria
A1 Martin, Vicente
A1 Vitelli-Storelli, Facundo
A1 Moreno, Victor
A1 Aragones, Nuria
A1 Ardanaz, Eva
A1 Alonso-Molero, Jessica
A1 Jimenez-Moleon, Jose J.
A1 Amiano, Pilar
A1 Fernandez-Tardon, Guillermo
A1 Molina-Barcelo, Ana
A1 Alguacil, Juan
A1 Dolores-Chirlaque, Maria
A1 Alvarez-Alvarez, Laura
A1 Perez-Gomez, Beatriz
A1 Dierssen-Sotos, Trinidad
A1 Olmedo-Requena, Rocio
A1 Guevara, Marcela
A1 Fernandez-Villa, Tania
A1 Pollan, Marina
A1 Benavente, Yolanda
K1 Colorectal cancer
K1 Family history
K1 Risk factor
K1 Case and control
K1 MCCSpain
K1 Colon-cancer
K1 Metaanalysis
K1 Impact
AB Objective: To evaluate the association between first-degree family history and colorectal cancer (CRC).Method: We analyzed data from 2857 controls and 1360 CRC cases, collected in the MCC-Spain project. The adjusted odds ratio (OR) and 95% confidence interval (95% CI) of association with the family history of CRC was estimated by non-conditional logistic regression.Result: First-degree relatives doubled the risk of CRC (OR: 2.19; 95% CI: 1.80-2.66), increasing in those with two or more (OR: 4.22; 95% CI: 2.29-7.78) and in those whose relatives were diagnosed before 50 years (OR: 3.24; 95% CI: 1.52-6.91). Regarding the association of the family history with the location, no significant differences were observed between colon and rectum, but there were in the relation of these with the age of diagnosis, having more relatives those diagnosed before 50 years (OR: 4.79; 95% CI: 2.65-8.65).Conclusions: First-degree relatives of CRC increase the chances of developing this tumor, they also increase when the relative is diagnosed at an early age. Therefore, it must be a target population on which to carry out prevention measures. (C) 2021 SESPAS. Published by Elsevier Espana, S.L.U.
PB Elsevier
SN 0213-9111
YR 2022
FD 2022-07-01
LK https://hdl.handle.net/10668/28067
UL https://hdl.handle.net/10668/28067
LA es
DS RISalud
RD Apr 8, 2025