RT Journal Article
T1 Plasma Amino Acid Concentrations in Patients with Alcohol and/or Cocaine Use Disorders and Their Association with Psychiatric Comorbidity and Sex.
A1 García-Marchena, Nuria
A1 Marcos, Alberto
A1 Flores-López, María
A1 Moreno-Fernández, Mario
A1 Requena-Ocaña, Nerea
A1 Porras-Perales, Oscar
A1 Torres-Galván, Sandra
A1 Araos, Pedro
A1 Serrano, Antonia
A1 Muga, Roberto
A1 Ruiz-Ruiz, Juan Jesús
A1 Rodríguez de Fonseca, Fernando
A1 Ambrosio, Emilio
A1 Pavón-Morón, Francisco Javier
K1 CE-LIF
K1 PRISM
K1 abstinence
K1 alcohol use disorder
K1 amino acids
K1 biomarker
K1 cocaine use disorder
K1 cross-sectional study
K1 psychiatric comorbidity
K1 sex
AB (1) Background: Co-occurrence of mental and substance use disorders (SUD) is prevalent, but complicates their clinical courses, and specific biomarkers are required. Amino acids are altered in primary mental disorders; however, little is known about SUD and psychiatric comorbidity. Because most psychiatric disorders and biomarkers show sex differences, we investigated amino acids in men and women with alcohol and/or cocaine use disorders (AUD and/or CUD) and psychiatric comorbidity. (2) Methods: A cross-sectional study was conducted in 295 participants, who were divided into four groups (AUD, n = 60; CUD, n = 41; AUD + CUD, n = 64; and control, n = 130). Participants were clinically assessed, and plasma amino acid concentrations were analyzed in relation to sex, diagnosis of SUD and psychiatric comorbidity (3) Results: In the total sample, there were sex differences, and women showed lower Iso, Leu, Gln and Glu than men. While patients with CUD and AUD + CUD had higher Glu, Gly, Orn and Ser than controls, patients with AUD showed no differences. In SUD, patients with psychiatric comorbidity had lower Orn and higher Ala than non-comorbid patients in the AUD group. (4) Conclusions: There was a dysregulation of plasma amino acids in abstinent patients with SUD. However, our results suggest the importance of considering the clinical characteristics and sex in the validity of amino acids as potential biomarkers for SUD.
SN 2227-9059
YR 2022
FD 2022-05-14
LK http://hdl.handle.net/10668/20832
UL http://hdl.handle.net/10668/20832
LA en
DS RISalud
RD Apr 5, 2025