TY - JOUR AU - Romeo-Guitart, David AU - Leiva-Rodríguez, Tatiana AU - Espinosa-Alcantud, María AU - Sima, Núria AU - Vaquero, Alejandro AU - Domínguez-Martín, Helena AU - Ruano, Diego AU - Casas, Caty PY - 2018 DO - 10.1038/s41419-018-0553-6 UR - http://hdl.handle.net/10668/12450 T2 - Cell death & disease AB - Sirtuin 1 (SIRT1) activity is neuroprotective, and we have recently demonstrated its role in the retrograde degenerative process in motoneurons (MNs) in the spinal cord of rats after peripheral nerve root avulsion (RA) injury. SIRT2 has been suggested... LA - en KW - Acamprosate KW - Animals KW - Benzamides KW - Drug Combinations KW - Endoplasmic Reticulum Stress KW - Enzyme Activation KW - Female KW - Hypoglossal Nerve Injuries KW - Mice KW - Mice, Knockout KW - Motor Neurons KW - Neuroprotection KW - Ribavirin KW - Sirtuin 1 KW - Sirtuin 2 KW - Sulfonamides TI - SIRT1 activation with neuroheal is neuroprotective but SIRT2 inhibition with AK7 is detrimental for disconnected motoneurons. TY - research article VL - 9 ER -