RT Journal Article
T1 Changes in IgE sensitization and total IgE levels over 20 years of follow-up.
A1 Amaral, André F S
A1 Newson, Roger B
A1 Abramson, Michael J
A1 Antó, Josep M
A1 Bono, Roberto
A1 Corsico, Angelo G
A1 de Marco, Roberto
A1 Demoly, Pascal
A1 Forsberg, Bertil
A1 Gislason, Thorarinn
A1 Heinrich, Joachim
A1 Huerta, Ismael
A1 Janson, Christer
A1 Jõgi, Rain
A1 Kim, Jeong-Lim
A1 Maldonado, José
A1 Martinez-Moratalla Rovira, Jesús
A1 Neukirch, Catherine
A1 Nowak, Dennis
A1 Pin, Isabelle
A1 Probst-Hensch, Nicole
A1 Raherison-Semjen, Chantal
A1 Svanes, Cecilie
A1 Urrutia Landa, Isabel
A1 van Ree, Ronald
A1 Versteeg, Serge A
A1 Weyler, Joost
A1 Zock, Jan-Paul
A1 Burney, Peter G J
A1 Jarvis, Deborah L
K1 Allergens
K1 IgE
K1 aging
K1 cohort study
K1 epidemiology
K1 immunosenescence
K1 longitudinal analysis
K1 sensitization
AB Cross-sectional studies have reported a lower prevalence of sensitization in older adults, but few longitudinal studies have examined whether this is an aging or a year-of-birth cohort effect. We sought to assess changes in sensitization and total IgE levels in a cohort of European adults as they aged over a 20-year period. Levels of serum specific IgE to common aeroallergens (house dust mite, cat, and grass) and total IgE levels were measured in 3206 adults from 25 centers in the European Community Respiratory Health Survey on 3 occasions over 20 years. Changes in sensitization and total IgE levels were analyzed by using regression analysis corrected for potential differences in laboratory equipment and by using inverse sampling probability weights to account for nonresponse. Over the 20-year follow-up, the prevalence of sensitization to at least 1 of the 3 allergens decreased from 29.4% to 24.8% (-4.6%; 95% CI, -7.0% to -2.1%). The prevalence of sensitization to house dust mite (-4.3%; 95% CI, -6.0% to -2.6%) and cat (-2.1%; 95% CI, -3.6% to -0.7%) decreased more than sensitization to grass (-0.6%; 95% CI, -2.5% to 1.3%). Age-specific prevalence of sensitization to house dust mite and cat did not differ between year-of-birth cohorts, but sensitization to grass was most prevalent in the most recent ones. Overall, total IgE levels decreased significantly (geometric mean ratio, 0.63; 95% CI, 0.58-0.68) at all ages in all year-of-birth cohorts. Aging was associated with lower levels of sensitization, especially to house dust mite and cat, after the age of 20 years.
YR 2015
FD 2015-11-14
LK http://hdl.handle.net/10668/9625
UL http://hdl.handle.net/10668/9625
LA en
DS RISalud
RD Apr 6, 2025