RT Journal Article
T1 Lung Deposition and Inspiratory Flow Rate in Patients with Chronic Obstructive Pulmonary Disease Using Different Inhalation Devices: A Systematic Literature Review and Expert Opinion.
A1 Baloira, Adolfo
A1 Abad, Araceli
A1 Fuster, Antonia
A1 García Rivero, Juan Luis
A1 García-Sidro, Patricia
A1 Márquez-Martín, Eduardo
A1 Palop, Marta
A1 Soler, Néstor
A1 Velasco, J L
A1 González-Torralba, Fernando
K1 COPD
K1 inhalation devices
K1 inspiratory flow
K1 lung deposition
K1 systematic literature review
AB Our aim was to describe: 1) lung deposition and inspiratory flow rate; 2) main characteristics of inhaler devices in chronic obstructive pulmonary disease (COPD). A systematic literature review (SLR) was conducted to analyze the features and results of inhaler devices in COPD patients. These devices included pressurized metered-dose inhalers (pMDIs), dry powder inhalers (DPIs), and a soft mist inhaler (SMI). Inclusion and exclusion criteria were established, as well as search strategies (Medline, Embase, and the Cochrane Library up to April 2019). In vitro and in vivo studies were included. Two reviewers selected articles, collected and analyzed data independently. Narrative searches complemented the SLR. We discussed the results of the reviews in a nominal group meeting and agreed on various general principles and recommendations. The SLR included 71 articles, some were of low-moderate quality, and there was great variability regarding populations and outcomes. Lung deposition rates varied across devices: 8%-53% for pMDIs, 7%-69% for DPIs, and 39%-67% for the SMI. The aerosol exit velocity was high with pMDIs (more than 3 m/s), while it is much slower (0.84-0.72 m/s) with the SMI. In general, pMDIs produce large-sized particles (1.22-8 μm), DPIs produce medium-sized particles (1.8-4.8 µm), and 60% of the particles reach an aerodynamic diameter  Lung deposition and inspiratory flow rate are key factors when selecting an inhalation device in COPD patients.
YR 2021
FD 2021-04-19
LK http://hdl.handle.net/10668/17644
UL http://hdl.handle.net/10668/17644
LA en
DS RISalud
RD Apr 10, 2025