RT Journal Article
T1 HoF3 and DyF3 Nanoparticles as Contrast Agents for High-Field Magnetic Resonance Imaging
A1 Gonzalez-Mancebo, Daniel
A1 Becerro, Ana I.
A1 Rojas, T. Cristina
A1 Garcia-Martin, Maria L.
A1 de la Fuente, Jesus M.
A1 Ocana, Manuel
K1 contrast agents
K1 dysprosium fluoride
K1 holmium fluoride
K1 magnetic resonance imaging (MRI)
K1 relaxivity
K1 In-vivo
K1 Nahof4 nanoparticles
K1 Ionic liquids
K1 Size
K1 Performance
K1 Tomography
K1 Cancer
K1 Probes
K1 Metal
K1 Oxide
AB Clinical contrast agents (CAs) currently used in magnetic resonance imaging (MRI) at low fields are less effective at high magnetic fields. The development of new CAs is mandatory to improve diagnostic capabilities of the new generation of high field MRI scanners. The purpose of this study is to synthesize uniform, water dispersible LnF(3) (Ln = Ho, Dy) nanoparticles (NPs) and to evaluate their relaxivity at high magnetic field (9.4 T) as a function of size and composition. Two different types of HoF3 NPs are obtained by homogeneous precipitation in ethylene glycol at 120 degrees C. The use of holmium acetate as holmium precursor leads to rhombus-like nanoparticles, while smaller, ellipsoid-like nanoparticles are obtained when nitrate is used as the holmium salt. To explain this behavior, the mechanism of formation of both kinds of particles is analyzed in detail. Likewise, rhombus-like DyF3 nanoparticles are prepared following the same method as for the rhombus-like HoF3 nanoparticles. We have found, to the best of knowledge, the highest transverse relaxivity values at 9.4 T described in the literature for this kind of CAs. Finally, the LnF(3) NPs have shown negligible cytotoxicity for C6 rat glioma cells for concentrations up to 0.1 mg mL(-1).
PB Wiley-v c h verlag gmbh
SN 0934-0866
YR 2017
FD 2017-10-01
LK http://hdl.handle.net/10668/18618
UL http://hdl.handle.net/10668/18618
LA en
DS RISalud
RD Apr 14, 2025