RT Journal Article
T1 Ustekinumab in Crohn's disease: real-world outcomes and predictors of response.
A1 Lorenzo González, Laura
A1 Valdés Delgado, Teresa
A1 Vázquez Morón, Juan María
A1 Castro Laria, Luisa
A1 Leo Carnerero, Eduardo
A1 Maldonado Pérez, María Belén
A1 Sánchez Capilla, Damián
A1 Pallarés Manrique, Héctor
A1 Sáez Díaz, Antonia
A1 Argüelles Arias, Federico
A1 Grupo de Enfermedad Inflamatoria de Andalucía, 
AB ustekinumab is a monoclonal antibody that inhibits interleukins IL-12 and IL-23, and is approved for the treatment of Crohn's disease (CD) and, more recently, also ulcerative colitis (UC). The aim of this study was to evaluate the effectiveness and safety of ustekinumab, as well as to identify possible predictive factors of response in a real-life setting. an observational, retrospective, multicenter study was carried out in 4 hospitals in Andalusia. Adult patients with a confirmed diagnosis of CD treated with ustekinumab from 2017 to 2019 were included. Clinical response was analyzed at 3, 6 and 12 months of treatment. Clinical disease activity was assessed with the Harvey-Bradshaw index (HBI) and the Crohn's Disease Activity Index (CDAI); biochemical response was assessed with lab parameters such as CRP and ESR. One-year ustekinumab drug-survival was analyzed. a total of 98 patients were analyzed (mean age, 43 years; 52 % were male); 56 % had failed with ≥ 2 previous biologicals therapies. At 3 months, 69 % of the patients were in response and 40.8 % in remission. At 6 months, 56 % were in clinical remission. At 12 months, 73.7 % were in clinical response and 60.5 % in remission. Corticosteroid-free remission was 32.4 %, 44 %, and 47.4 % at 3, 6, and 12 months, respectively. Cumulative survival after one year of treatment with ustekinumab was 85.3 %. Biochemical parameters such as CRP and ESR showed a statistically significant decrease between baseline and control levels at 3, 6, and 12 months. A lower HBI at baseline and female sex were predictors of corticosteroid-free clinical remission in a univariate analysis. In the multivariate analysis no variables were found as predictors of corticosteroid-free clinical remission. ustekinumab therapy is safe and useful, inducing clinical response in more than 50 % of patients, including patients who failed with other biological therapies.
SN 1130-0108
YR 2022
FD 2022
LK http://hdl.handle.net/10668/21699
UL http://hdl.handle.net/10668/21699
LA en
DS RISalud
RD Apr 17, 2025