RT Journal Article T1 Comparative Study between the Combination of Dexamethasone and Bupivacaine for Third Molar Surgery Postoperative Pain: A Triple-Blind, Randomized Clinical Trial A1 Javier Quesada-Bravo, Francisco A1 Rocio Garcia-Carricondo, Ana A1 Espin-Galvez, Fernando A1 Fernandez-Sanchez, Carmen A1 Fernandez-Gines, Damaso A1 del Mar Requena-Mullor, Maria A1 Alarcon-Rodriguez, Raquel K1 third molar surgery K1 bupivacaine K1 dexamethasone K1 submucosa K1 postoperative pain K1 Surgical extraction K1 Corticosteroids K1 Efficacy K1 Sequelae K1 Submucosal K1 Analgesia K1 Articaine K1 Removal K1 Relief K1 Safety AB Objectives: To compare the possible benefits of the combination of dexamethasone-bupivacaine with articaine-epinephrine as an anaesthetic block after third molar surgery. Materials and Methods: Triple-blind, randomized, controlled, parallel, phase 3 clinical trial. Two groups: experimental (93 patients) with standard anaesthetic block: 40/0.005 mg/mL articaine-epinephrine and submucosal reinforcement with 0.8 mg dexamethasone-5% bupivacaine; and control group (91 patients) with standard block: 40/0.005 mg/mL articaine-epinephrine. The surgery consisted of the extraction of the impacted mandibular third molar by performing a procedure following the same repeatable scheme. The visual analogue scale (VAS) was used to analyse postoperative pain. Results: Groups were homogeneous, without significant differences related to epidemiological variables. Postoperative pain among the first, second, and seventh postoperative days was statistically significantly lower in the experimental group compared to the control group (p PB Mdpi YR 2021 FD 2021-11-01 LK https://hdl.handle.net/10668/24933 UL https://hdl.handle.net/10668/24933 LA en DS RISalud RD Apr 6, 2025