RT Journal Article
T1 Immunomodulatory Response of Toll-like Receptor Ligand-Peptide Conjugates in Food Allergy
A1 Losada Mendez, Jorge
A1 Palomares, Francisca
A1 Gomez, Francisca
A1 Ramirez-Lopez, Pedro
A1 Ramos-Soriano, Javier
A1 Jose Torres, Maria
A1 Mayorga, Cristobalina
A1 Rojo, Javier
K1 Monophosphoryl-lipid-a
K1 Dendritic cells
K1 Innate immunity
K1 Immunotherapy
K1 Recognition
K1 Vaccines
K1 Identification
K1 Modulation
K1 Activation
K1 Gsk2245035
AB Covalent conjugation of allergens to toll-like receptor (TLR) agonists appears to be a powerful strategy for the development of safety compounds for allergen-specific immunomodulatory response toward tolerance in allergy. In this work, we have synthesized two family of ligands, an 8-oxoadenine derivative as a ligand for TLR7 and a pyrimido[5,4-b]indole as a ligand for TLR4, both conjugated with a T-cell peptide of Pru p 3 allergen, the lipid transfer protein (LTP) responsible for LTP-dependent food allergy. These conjugates interact with dendritic cells, inducing their specific maturation, T-cell proliferation, and cytokine production in peach allergic patients. Moreover, they increased the Treg-cell frequencies in these patients and could induce the IL-10 production. These outcomes were remarkable in the case of the TLR7 ligand conjugated with Pru p 3, opening the door for the potential application of these allergen-adjuvant systems in food allergy immunotherapy.
PB Amer chemical soc
SN 1554-8929
YR 2021
FD 2021-11-11
LK https://hdl.handle.net/10668/24541
UL https://hdl.handle.net/10668/24541
LA en
DS RISalud
RD Apr 10, 2025