%0 Journal Article
%A Losada Mendez, Jorge
%A Palomares, Francisca
%A Gomez, Francisca
%A Ramirez-Lopez, Pedro
%A Ramos-Soriano, Javier
%A Jose Torres, Maria
%A Mayorga, Cristobalina
%A Rojo, Javier
%T Immunomodulatory Response of Toll-like Receptor Ligand-Peptide Conjugates in Food Allergy
%D 2021
%@ 1554-8929
%U https://hdl.handle.net/10668/24541
%X Covalent conjugation of allergens to toll-like receptor (TLR) agonists appears to be a powerful strategy for the development of safety compounds for allergen-specific immunomodulatory response toward tolerance in allergy. In this work, we have synthesized two family of ligands, an 8-oxoadenine derivative as a ligand for TLR7 and a pyrimido[5,4-b]indole as a ligand for TLR4, both conjugated with a T-cell peptide of Pru p 3 allergen, the lipid transfer protein (LTP) responsible for LTP-dependent food allergy. These conjugates interact with dendritic cells, inducing their specific maturation, T-cell proliferation, and cytokine production in peach allergic patients. Moreover, they increased the Treg-cell frequencies in these patients and could induce the IL-10 production. These outcomes were remarkable in the case of the TLR7 ligand conjugated with Pru p 3, opening the door for the potential application of these allergen-adjuvant systems in food allergy immunotherapy.
%K Monophosphoryl-lipid-a
%K Dendritic cells
%K Innate immunity
%K Immunotherapy
%K Recognition
%K Vaccines
%K Identification
%K Modulation
%K Activation
%K Gsk2245035
%~