RT Journal Article
T1 Synaptic processes and immune-related pathways implicated in Tourette syndrome.
A1 Tsetsos, Fotis
A1 Yu, Dongmei
A1 Sul, Jae Hoon
A1 Huang, Alden Y
A1 Illmann, Cornelia
A1 Osiecki, Lisa
A1 Darrow, Sabrina M
A1 Hirschtritt, Matthew E
A1 Greenberg, Erica
A1 Muller-Vahl, Kirsten R
A1 Stuhrmann, Manfred
A1 Dion, Yves
A1 Rouleau, Guy A
A1 Aschauer, Harald
A1 Stamenkovic, Mara
A1 Schlögelhofer, Monika
A1 Sandor, Paul
A1 Barr, Cathy L
A1 Grados, Marco A
A1 Singer, Harvey S
A1 Nöthen, Markus M
A1 Hebebrand, Johannes
A1 Hinney, Anke
A1 King, Robert A
A1 Fernandez, Thomas V
A1 Barta, Csaba
A1 Tarnok, Zsanett
A1 Nagy, Peter
A1 Depienne, Christel
A1 Worbe, Yulia
A1 Hartmann, Andreas
A1 Budman, Cathy L
A1 Rizzo, Renata
A1 Lyon, Gholson J
A1 McMahon, William M
A1 Batterson, James R
A1 Cath, Danielle C
A1 Malaty, Irene A
A1 Okun, Michael S
A1 Berlin, Cheston
A1 Woods, Douglas W
A1 Lee, Paul C
A1 Jankovic, Joseph
A1 Robertson, Mary M
A1 Gilbert, Donald L
A1 Brown, Lawrence W
A1 Coffey, Barbara J
A1 Dietrich, Andrea
A1 Hoekstra, Pieter J
A1 Kuperman, Samuel
A1 Zinner, Samuel H
A1 Wagner, Michael
A1 Knowles, James A
A1 Jeremy Willsey, A
A1 Tischfield, Jay A
A1 Heiman, Gary A
A1 Cox, Nancy J
A1 Freimer, Nelson B
A1 Neale, Benjamin M
A1 Davis, Lea K
A1 Coppola, Giovanni
A1 Mathews, Carol A
A1 Scharf, Jeremiah M
A1 Paschou, Peristera
A1 Tourette Association of America International Consortium for Genetics, 
A1 Barr, Cathy L
A1 Batterson, James R
A1 Berlin, Cheston
A1 Budman, Cathy L
A1 Cath, Danielle C
A1 Coppola, Giovanni
A1 Cox, Nancy J
A1 Darrow, Sabrina
A1 Davis, Lea K
A1 Dion, Yves
A1 Freimer, Nelson B
A1 Grados, Marco A
A1 Greenberg, Erica
A1 Hirschtritt, Matthew E
A1 Huang, Alden Y
A1 Illmann, Cornelia
A1 King, Robert A
A1 Kurlan, Roger
A1 Leckman, James F
A1 Lyon, Gholson J
A1 Malaty, Irene A
A1 Mathews, Carol A
A1 McMahon, William M
A1 Neale, Benjamin M
A1 Okun, Michael S
A1 Osiecki, Lisa
A1 Robertson, Mary M
A1 Rouleau, Guy A
A1 Sandor, Paul
A1 Scharf, Jeremiah M
A1 Singer, Harvey S
A1 Smit, Jan H
A1 Sul, Jae Hoon
A1 Yu, Dongmei
A1 Gilles de la Tourette GWAS Replication Initiative, 
A1 Aschauer, Harald Aschauer Harald
A1 Barta, Csaba
A1 Budman, Cathy L
A1 Cath, Danielle C
A1 Depienne, Christel
A1 Hartmann, Andreas
A1 Hebebrand, Johannes
A1 Konstantinidis, Anastasios
A1 Mathews, Carol A
A1 Müller-Vahl, Kirsten
A1 Nagy, Peter
A1 Nöthen, Markus M
A1 Paschou, Peristera
A1 Rizzo, Renata
A1 Rouleau, Guy A
A1 Sandor, Paul
A1 Scharf, Jeremiah M
A1 Schlögelhofer, Monika
A1 Stamenkovic, Mara
A1 Stuhrmann, Manfred
A1 Tsetsos, Fotis
A1 Tarnok, Zsanett
A1 Wolanczyk, Tomasz
A1 Worbe, Yulia
A1 Tourette International Collaborative Genetics Study, 
A1 Brown, Lawrence
A1 Cheon, Keun-Ah
A1 Coffey, Barbara J
A1 Dietrich, Andrea
A1 Fernandez, Thomas V
A1 Garcia-Delgar, Blanca
A1 Gilbert, Donald
A1 Grice, Dorothy E
A1 Hagstrøm, Julie
A1 Hedderly, Tammy
A1 Heiman, Gary A
A1 Heyman, Isobel
A1 Hoekstra, Pieter J
A1 Huyser, Chaim
A1 Kim, Young Key
A1 Kim, Young-Shin
A1 King, Robert A
A1 Koh, Yun-Joo
A1 Kook, Sodahm
A1 Kuperman, Samuel
A1 Leventhal, Bennett L
A1 Madruga-Garrido, Marcos
A1 Mir, Pablo
A1 Morer, Astrid
A1 Münchau, Alexander
A1 Plessen, Kerstin J
A1 Roessner, Veit
A1 Shin, Eun-Young
A1 Song, Dong-Ho
A1 Song, Jungeun
A1 Tischfield, Jay A
A1 Willsey, A Jeremy
A1 Zinner, Samuel
A1 Psychiatric Genomics Consortium Tourette Syndrome Working Group, 
A1 Aschauer, Harald
A1 Barr, Cathy L
A1 Barta, Csaba
A1 Batterson, James R
A1 Berlin, Cheston
A1 Brown, Lawrence
A1 Budman, Cathy L
A1 Cath, Danielle C
A1 Coffey, Barbara J
A1 Coppola, Giovanni
A1 Cox, Nancy J
A1 Darrow, Sabrina
A1 Davis, Lea K
A1 Depienne, Christel
A1 Dietrich, Andrea
A1 Dion, Yves
A1 Fernandez, Thomas
A1 Freimer, Nelson B
A1 Gilbert, Donald
A1 Grados, Marco A
A1 Greenberg, Erica
A1 Hartmann, Andreas
A1 Hebebrand, Johannes
A1 Heiman, Gary
A1 Hirschtritt, Matthew E
A1 Hoekstra, Pieter
A1 Huang, Alden Y
A1 Illmann, Cornelia
A1 Jankovic, Joseph
A1 King, Robert A
A1 Kuperman, Samuel
A1 Lee, Paul C
A1 Lyon, Gholson J
A1 Malaty, Irene A
A1 Mathews, Carol A
A1 McMahon, William M
A1 Müller-Vahl, Kirsten
A1 Nagy, Peter
A1 Neale, Benjamin M
A1 Nöthen, Markus M
A1 Okun, Michael S
A1 Osiecki, Lisa
A1 Paschou, Peristera
A1 Rizzo, Renata
A1 Robertson, Mary M
A1 Rouleau, Guy A
A1 Sandor, Paul
A1 Scharf, Jeremiah M
A1 Schlögelhofer, Monika
A1 Singer, Harvey S
A1 Stamenkovic, Mara
A1 Stuhrmann, Manfred
A1 Sul, Jae Hoon
A1 Tarnok, Zsanett
A1 Tischfield, Jay
A1 Tsetsos, Fotis
A1 Willsey, A Jeremy
A1 Woods, Douglas
A1 Worbe, Yulia
A1 Yu, Dongmei
A1 Zinner, Samuel
AB Tourette syndrome (TS) is a neuropsychiatric disorder of complex genetic architecture involving multiple interacting genes. Here, we sought to elucidate the pathways that underlie the neurobiology of the disorder through genome-wide analysis. We analyzed genome-wide genotypic data of 3581 individuals with TS and 7682 ancestry-matched controls and investigated associations of TS with sets of genes that are expressed in particular cell types and operate in specific neuronal and glial functions. We employed a self-contained, set-based association method (SBA) as well as a competitive gene set method (MAGMA) using individual-level genotype data to perform a comprehensive investigation of the biological background of TS. Our SBA analysis identified three significant gene sets after Bonferroni correction, implicating ligand-gated ion channel signaling, lymphocytic, and cell adhesion and transsynaptic signaling processes. MAGMA analysis further supported the involvement of the cell adhesion and trans-synaptic signaling gene set. The lymphocytic gene set was driven by variants in FLT3, raising an intriguing hypothesis for the involvement of a neuroinflammatory element in TS pathogenesis. The indications of involvement of ligand-gated ion channel signaling reinforce the role of GABA in TS, while the association of cell adhesion and trans-synaptic signaling gene set provides additional support for the role of adhesion molecules in neuropsychiatric disorders. This study reinforces previous findings but also provides new insights into the neurobiology of TS.
YR 2021
FD 2021-01-18
LK https://hdl.handle.net/10668/25697
UL https://hdl.handle.net/10668/25697
LA en
DS RISalud
RD Apr 11, 2025