RT Journal Article
T1 Parity, breastfeeding and risk of coronary heart disease: A pan-European case-cohort study.
A1 Peters, Sanne Ae
A1 van der Schouw, Yvonne T
A1 Wood, Angela M
A1 Sweeting, Michael J
A1 Moons, Karel Gm
A1 Weiderpass, Elisabete
A1 Arriola, Larraitz
A1 Benetou, Vassiliki
A1 Boeing, Heiner
A1 Bonnet, Fabrice
A1 Butt, Salma T
A1 Clavel-Chapelon, Françoise
A1 Drake, Isabel
A1 Gavrila, Diana
A1 Key, Timothy J
A1 Klinaki, Eleni
A1 Krogh, Vittorio
A1 Kühn, Tilman
A1 Lassale, Camille
A1 Masala, Giovanna
A1 Matullo, Giuseppe
A1 Merritt, Melissa
A1 Molina-Portillo, Elena
A1 Moreno-Iribas, Conchi
A1 Nøst, Therese H
A1 Olsen, Anja
A1 Onland-Moret, N Charlotte
A1 Overvad, Kim
A1 Panico, Salvatore
A1 Redondo, M Luisa
A1 Tjønneland, Anne
A1 Trichopoulou, Antonia
A1 Tumino, Rosario
A1 Turzanski-Fortner, Renée
A1 Tzoulaki, Ioanna
A1 Wennberg, Patrik
A1 Winkvist, Anna
A1 Thompson, Simon G
A1 Di Angelantonio, Emanuele
A1 Riboli, Elio
A1 Wareham, Nicholas J
A1 Danesh, John
A1 Butterworth, Adam S
K1 Parity
K1 Women
K1 breastfeeding
K1 coronary heart disease
AB There is uncertainty about the direction and magnitude of the associations between parity, breastfeeding and the risk of coronary heart disease (CHD). We examined the separate and combined associations of parity and breastfeeding practices with the incidence of CHD later in life among women in a large, pan-European cohort study. Data were used from European Prospective Investigation into Cancer and Nutrition (EPIC)-CVD, a case-cohort study nested within the EPIC prospective study of 520,000 participants from 10 countries. Information on reproductive history was available for 14,917 women, including 5138 incident cases of CHD. Using Prentice-weighted Cox regression separately for each country followed by a random-effects meta-analysis, we calculated hazard ratios (HRs) and 95% confidence intervals (CIs) for CHD, after adjustment for age, study centre and several socioeconomic and biological risk factors. Compared with nulliparous women, the adjusted HR was 1.19 (95% CI: 1.01-1.41) among parous women; HRs were higher among women with more children (e.g., adjusted HR: 1.95 (95% CI: 1.19-3.20) for women with five or more children). Compared with women who did not breastfeed, the adjusted HR was 0.71 (95% CI: 0.52-0.98) among women who breastfed. For childbearing women who never breastfed, the adjusted HR was 1.58 (95% CI: 1.09-2.30) compared with nulliparous women, whereas for childbearing women who breastfed, the adjusted HR was 1.19 (95% CI: 0.99-1.43). Having more children was associated with a higher risk of CHD later in life, whereas breastfeeding was associated with a lower CHD risk. Women who both had children and breastfed did have a non-significantly higher risk of CHD.
YR 2016
FD 2016-07-04
LK http://hdl.handle.net/10668/10242
UL http://hdl.handle.net/10668/10242
LA en
DS RISalud
RD Apr 7, 2025