TY  - JOUR
AU  - Vazquez, M J
AU  - Toro, C A
AU  - Castellano, J M
AU  - Ruiz-Pino, F
AU  - Roa, J
AU  - Beiroa, D
AU  - Heras, V
AU  - Velasco, I
AU  - Dieguez, C
AU  - Pinilla, L
AU  - Gaytan, F
AU  - Nogueiras, R
AU  - Bosch, M A
AU  - Rønnekleiv, O K
AU  - Lomniczi, A
AU  - Ojeda, S R
AU  - Tena-Sempere, M
PY  - 2018
DO  - 10.1038/s41467-018-06459-9
UR  - http://hdl.handle.net/10668/13058
T2  - Nature communications
AB  - Puberty is regulated by epigenetic mechanisms and is highly sensitive to metabolic and nutritional cues. However, the epigenetic pathways mediating the effects of nutrition and obesity on pubertal timing are unknown. Here, we identify Sirtuin 1...
LA  - en
PB  - Nature Publishing Group
KW  - Nutritional Physiological Phenomena
KW  - Nutritional Status
KW  - Obesity
KW  - Polycomb Repressive Complex 2
KW  - Promoter Regions, Genetic
KW  - Rats, Wistar
KW  - Sexual Maturation
KW  - Animals
KW  - Arcuate Nucleus of Hypothalamus
KW  - Chromatin
KW  - Epigenesis, Genetic
KW  - Female
KW  - Histones
KW  - Hypothalamus
KW  - Kisspeptins
KW  - Mice, Transgenic
KW  - Models, Biological
KW  - Neurons
TI  - SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression.
TY  - research article
VL  - 9
ER  -