RT Journal Article
T1 Neonatal oropharyngeal infection by HPV in our area.
A1 Elósegui, Jesús Joaquín Hijona
A1 Torices, María Soledad Sánchez
A1 Rísquez, Ana Cristina Fernández
A1 Montes, Juan Francisco Expósito
A1 García, Antonio Luis Carballo
K1 Human papillomavirus
K1 Orofaringe
K1 Oropharynx
K1 Perinatal
K1 Transmisión vertical
K1 Vertical transmission
K1 Virus del papiloma humano
AB Although infection by human papillomavirus (HPV) is mainly considered a sexually transmitted disease, newborns exposed to the virus in the perinatal period can also be infected through mechanisms that are not yet fully understood. The aim of our study was to increase our understanding of neonatal oropharyngeal infection by HPV, trying to establish its frequency, mechanisms of infection and persistence through age 2 years. We conducted a prospective, observational and descriptive study in a cohort of neonates born vaginally whose mothers carried HPV in the lower genital tract at the time of delivery. Tests for detection of HPV in amniotic fluid, venous cord blood and oropharyngeal secretions were performed in every neonate, and we conducted microbiological follow-up of infants colonized by HPV up to age 2 years. The prevalence of oropharyngeal colonization at birth was 58.24%. In the 24-month follow-up, the proportions of clearance and persistence of HPV in the oropharynx were 94.34% and 5.66%, respectively. The results of this case series suggest that neonatal oropharyngeal colonization by HPV, while frequent in the postpartum period, is usually a self-limited process, and the main mechanism of infection transvaginal intrapartum vertical transmission. Although colonization in most neonates is transient and asymptomatic, the clinical significance of persistent carriage remains unknown.
YR 2022
FD 2022-07-15
LK http://hdl.handle.net/10668/21921
UL http://hdl.handle.net/10668/21921
LA en
DS RISalud
RD Apr 6, 2025