%0 Journal Article
%A Rodilla, Enrique
%A Saura, Alberto
%A Jiménez, Iratxe
%A Mendizábal, Andrea
%A Pineda-Cantero, Araceli
%A Lorenzo-Hernández, Elizabeth
%A Fidalgo-Montero, Maria del Pilar
%A Fernandez López-Cuervo, Joaquín
%A Gil-Sánchez, Ricardo
%A Rabadán-Pejenaute, Elisa
%A Abella-Vázquez, Lucy
%A Giner-Galvañ, Vicente
%A Solís-Marquínez, Marta Nataya
%A Boixeda, Ramon
%A de la Peña-Fernández, Andrés
%A Carrasco-Sánchez, Francisco Javier
%A González-Moraleja, Julio
%A Torres-Peña, José David
%A Guisado-Espartero, María Esther
%A Escobar-Sevilla, Joaquín
%A Guzmán-García, Marcos
%A Martín-Escalante, María Dolores
%A Martínez-González, Ángel Luis
%A Casas-Rojo, José Manuel
%A Gómez-Huelgas, Ricardo
%T Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19
%D 2020
%U http://hdl.handle.net/10668/3366
%X It is unclear to which extent the higher mortality associated with hypertension in the coronavirus disease (COVID-19) is due to its increased prevalence among older patients or to specific mechanisms. Cross-sectional, observational, retrospective multicenter study, analyzing 12226 patients who required hospital admission in 150 Spanish centers included in the nationwide SEMI-COVID-19 Network. We compared the clinical characteristics of survivors versus non-survivors. The mean age of the study population was 67.5 ± 16.1 years, 42.6% were women. Overall, 2630 (21.5%) subjects died. The most common comorbidity was hypertension (50.9%) followed by diabetes (19.1%), and atrial fibrillation (11.2%). Multivariate analysis showed that after adjusting for gender (males, OR: 1.5, p = 0.0001), age tertiles (second and third tertiles, OR: 2.0 and 4.7, p = 0.0001), and Charlson Comorbidity Index scores (second and third tertiles, OR: 4.7 and 8.1, p = 0.0001), hypertension was significantly predictive of all-cause mortality when this comorbidity was treated with angiotensin-converting enzyme inhibitors (ACEIs) (OR: 1.6, p = 0.002) or other than renin-angiotensin-aldosterone blockers (OR: 1.3, p = 0.001) or angiotensin II receptor blockers (ARBs) (OR: 1.2, p = 0.035). The preexisting condition of hypertension had an independent prognostic value for all-cause mortality in patients with COVID-19 who required hospitalization. ARBs showed a lower risk of lethality in hypertensive patients than other antihypertensive drugs.
%K Hypertension
%K COVID-19
%K Angiotensin-converting enzyme inhibitors (ACEIs)
%K Angiotensin II receptor blockers (ARBs)
%K All-cause mortality
%K Hipertensión
%K Infecciones por coronavirus
%K Antagonistas de receptores de angiotensina
%K Inhibidores de la enzima convertidora de angiotensina
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