TY - JOUR AU - Codony, Sandra AU - Entrena, José M AU - Calvó-Tusell, Carla AU - Jora, Beatrice AU - González-Cano, Rafael AU - Osuna, Sílvia AU - Corpas, Rubén AU - Morisseau, Christophe AU - Pérez, Belén AU - Barniol-Xicota, Marta AU - Griñán-Ferré, Christian AU - Pérez, Concepción AU - Rodríguez-Franco, María Isabel AU - Martínez, Antón L AU - Loza, M Isabel AU - Pallàs, Mercè AU - Verhelst, Steven H L AU - Sanfeliu, Coral AU - Feixas, Ferran AU - Hammock, Bruce D AU - Brea, José AU - Cobos, Enrique J AU - Vázquez, Santiago PY - 2022 DO - 10.1021/acs.jmedchem.2c00515 UR - http://hdl.handle.net/10668/22591 T2 - Journal of medicinal chemistry AB - The soluble epoxide hydrolase (sEH) has been suggested as a pharmacological target for the treatment of several diseases, including pain-related disorders. Herein, we report further medicinal chemistry around new benzohomoadamantane-based sEH... LA - en KW - Mice KW - Humans KW - Animals KW - Epoxide Hydrolases KW - Urea KW - Disease Models, Animal KW - Visceral Pain KW - Capsaicin KW - Enzyme Inhibitors KW - Analgesics KW - Cyclophosphamide TI - Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors. TY - research article VL - 65 ER -