RT Journal Article
T1 Association of CRTC1 polymorphisms with obesity markers in subjects from the general population with lifetime depression.
A1 Quteineh, Lina
A1 Preisig, Martin
A1 Rivera, Margarita
A1 Milaneschi, Yuri
A1 Castelao, Enrique
A1 Gholam-Rezaee, Mehdi
A1 Vandenberghe, Frederik
A1 Saigi-Morgui, Nuria
A1 Delacrétaz, Aurélie
A1 Cardinaux, Jean-René
A1 Willemsen, Gonneke
A1 Boomsma, Dorret I
A1 Penninx, Brenda W J H
A1 Ching-López, Ana
A1 Conus, Philippe
A1 Eap, Chin B
K1 Genetic polymorphisms
K1 Major depressive disorder
K1 Obesity
K1 Pharmacogenetics
K1 Psychiatric disorders
K1 Psychotropic drugs
AB Psychiatric disorders have been hypothesized to share common etiological pathways with obesity, suggesting related neurobiological bases. We aimed to examine whether CRTC1 polymorphisms were associated with major depressive disorder (MDD) and to test the association of these polymorphisms with obesity markers in several large case-control samples with MDD. The association between CRTC1 polymorphisms and MDD was investigated in three case-control samples with MDD (PsyCoLaus n1=3,362, Radiant n2=3,148 and NESDA/NTR n3=4,663). The effect of CRTC1 polymorphisms on obesity markers was then explored. CRTC1 polymorphisms were not associated with MDD in the three samples. CRTC1 rs6510997C>T was significantly associated with fat mass in the PsyCoLaus study. In fact, a protective effect of this polymorphism was found in MDD cases (n=1,434, β=-1.32%, 95% CI -2.07 to -0.57, pT was significantly associated with fat mass in the PsyCoLaus study. In fact, a protective effect of this polymorphism was found in MDD cases (n=1,434, β=-1.32%, 95% CI -2.07 to -0.57, p Estimated fat mass using bioimpedance that capture more accurately adiposity was only present in the PsyCoLaus sample. CRTC1 polymorphisms seem to play a role with obesity markers in individuals with MDD rather than non-depressive individuals. Therefore, the weak association previously reported in the population-based samples was driven by cases diagnosed with lifetime MDD. However, CRTC1 seems not to be implicated directly in the development of psychiatric diseases.
YR 2016
FD 2016-03-10
LK http://hdl.handle.net/10668/9935
UL http://hdl.handle.net/10668/9935
LA en
DS RISalud
RD Apr 5, 2025