RT Journal Article T1 Diagnosis, prognosis, and treatment of brief psychotic episodes: a review and research agenda. A1 Fusar-Poli, Paolo A1 Salazar de Pablo, Gonzalo A1 Rajkumar, Ravi Philip A1 López-Díaz, Álvaro A1 Malhotra, Savita A1 Heckers, Stephan A1 Lawrie, Stephen M A1 Pillmann, Frank AB Brief psychotic episodes represent an intriguing paradox in clinical psychiatry because they elude the standard knowledge that applies to the persisting psychotic disorders such as schizophrenia. This Review describes key diagnostic considerations such as conceptual foundations, current psychiatric classification versus research-based operationalisations, epidemiology, and sociocultural variations; prognostic aspects including the risk of psychosis recurrence, types of psychotic recurrences, other clinical outcomes, prognostic factors; and therapeutic issues such as treatment guidelines and unmet need of care. The advances and challenges associated with the scientific evidence are used to set a research agenda in this area. We conclude that brief psychotic episodes can be reconceptualised within a clinical staging model to promote innovative translational research and improve our understanding and treatment of psychotic disorders. YR 2021 FD 2021-11-29 LK http://hdl.handle.net/10668/22558 UL http://hdl.handle.net/10668/22558 LA en DS RISalud RD Apr 7, 2025