RT Journal Article
T1 Meta-Analysis of Individual Patient Data of Sodium Bicarbonate and Sodium Chloride for All-Cause Mortality After Coronary Angiography.
A1 Brown, Jeremiah R
A1 Pearlman, Daniel M
A1 Marshall, Emily J
A1 Alam, Shama S
A1 MacKenzie, Todd A
A1 Recio-Mayoral, Alejandro
A1 Gomes, Vitor O
A1 Kim, Bokyung
A1 Jensen, Lisette O
A1 Mueller, Christian
A1 Maioli, Mauro
A1 Solomon, Richard J
AB We sought to examine the relation between sodium bicarbonate prophylaxis for contrast-associated nephropathy (CAN) and mortality. We conducted an individual patient data meta-analysis from multiple randomized controlled trials. We obtained individual patient data sets for 7 of 10 eligible trials (2,292 of 2,764 participants). For the remaining 3 trials, time-to-event data were imputed based on follow-up periods described in their original reports. We included all trials that compared periprocedural intravenous sodium bicarbonate to periprocedural intravenous sodium chloride in patients undergoing coronary angiography or other intra-arterial interventions. Included trials were determined by consensus according to predefined eligibility criteria. The primary outcome was all-cause mortality hazard, defined as time from randomization to death. In 10 trials with a total of 2,764 participants, sodium bicarbonate was associated with lower mortality hazard than sodium chloride at 1 year (hazard ratio 0.61, 95% confidence interval [CI] 0.41 to 0.89, p = 0.011). Although periprocedural sodium bicarbonate was associated with a reduction in the incidence of CAN (relative risk 0.75, 95% CI 0.62 to 0.91, p = 0.003), there exists a statistically significant interaction between the effect on mortality and the occurrence of CAN (hazard ratio 5.65, 95% CI 3.58 to 8.92, p
YR 2016
FD 2016-08-24
LK http://hdl.handle.net/10668/10456
UL http://hdl.handle.net/10668/10456
LA en
DS RISalud
RD Apr 9, 2025