RT Journal Article
T1 Integrating Comorbidities and Phenotype-Based Medicine in Patient-Centered Medicine in COPD
A1 Lopez-Campos, José Luis
A1 Ruiz-Duque, Borja
A1 Carrasco-Hernandez, Laura
A1 Caballero-Eraso, Candelaria
K1 COPD
K1 Clinical phenotypes
K1 Comorbidities
K1 Personalized medicine
K1 Enfermedad pulmonar obstructiva crónica
K1 Fenotipo
K1 Comorbilidad
K1 Medicina de precisión
K1 Pacientes
AB Despite recent notable innovations in the management of chronic obstructive pulmonary disease (COPD), no major advances in patient-centered medicine have been achieved. Current guidelines base their proposals on the average results from clinical trials, leading to what could be termed 'means-based' medical practice. However, the therapeutic response is variable at the patient level. Additionally, the variability of the clinical presentation interacts with comorbidities to form a complex clinical scenario for clinicians to deal with. Consequently, no consensus has been reached over a practical approach for combining comorbidities and disease presentation markers in the therapeutic algorithm. In this context, from the patients' first visit, the clinician faces four major dilemmas: (1) establishing the correct diagnosis of COPD as opposed to other airway diseases, such as bronchial asthma; (2) deciding on the initial therapeutic approach based on the clinical characteristics of each case; (3) setting up a study strategy for non-responding patients; (4) pursuing a follow-up strategy with two well-defined periods according to whether close or long-term follow-up is required. Here, we will address these major dilemmas in the search for a patient-centered approach to COPD management and suggest how to combine them all in a single easy-to-use strategy.
PB MDPI
YR 2020
FD 2020-08-25
LK http://hdl.handle.net/10668/3765
UL http://hdl.handle.net/10668/3765
LA en
NO Lopez-Campos JL, Ruiz-Duque B, Carrasco-Hernandez L, Caballero-Eraso C. Integrating Comorbidities and Phenotype-Based Medicine in Patient-Centered Medicine in COPD. J Clin Med. 2020 Aug 25;9(9):2745
DS RISalud
RD Apr 6, 2025