RT Journal Article
T1 Long-term safety and efficacy study of a medical device containing xyloglucan, pea protein reticulated with tannins and xylo-oligosaccharides, in patients with diarrhoea-predominant irritable bowel syndrome.
A1 de Los Rios, Constanza Ciriza
A1 Falcón, Blanca Serrano
A1 Arguelles-Arias, Federico
A1 Pérez, Esperanza
A1 Teruel, Carlos
A1 Geijo, Fernando
A1 Rey, Enrique
K1 diarrhoea
K1 gut permeability
K1 irritable bowel syndrome
K1 mucoprotectants
K1 xylo-oligosaccharides
K1 xyloglucan
AB Irritable bowel syndrome with diarrhoea (IBS-D) is a frequent problem associated with a significant socioeconomic implication. Increased gut permeability is an important pathophysiological mechanism. A medical device containing xyloglucan (XG), pea protein and tannins (PPT) from grape-seed extract, and xylo-oligosaccharides (XOS) has proven restoration of intestinal barrier function. Our objective was to evaluate the efficacy and safety of treatment with the medical device XG + PPT + XOS (XG-PPT-XOS) in adult patients with IBS-D in a clinical setting for 6 months. This was a multicentre, open-label, prospective, observational study conducted to evaluate long-term safety and efficacy of XG-PPT-XOS. IBS-D adult patients (Rome IV criteria) were included and received two tablets twice daily for 6 months. IBS Symptom Severity Score (IBS-SSS) and bowel habit were registered at baseline and monthly, until the end of follow up. Efficacy was evaluated by comparison of mean scores at each time point. 50 patients were included, of which 19 completed the 6 months. IBS-SSS score decreased from 312.2 ± 82.2 to 213.6 ± 109.9 (p  Treating IBS-D patients with XG-PPT-XOS is effective and safe in the long term within a clinical setting, improving all IBS-D symptoms from the first month of treatment and showing a sustained response over the term of therapy.
SN 1756-283X
YR 2021
FD 2021-05-30
LK https://hdl.handle.net/10668/25737
UL https://hdl.handle.net/10668/25737
LA en
DS RISalud
RD Apr 5, 2025