RT Journal Article
T1 Inter-Reader Reliability of Early FDG-PET/CT Response Assessment Using the Deauville Scale after 2 Cycles of Intensive Chemotherapy (OEPA) in Hodgkin's Lymphoma.
A1 Kluge, Regine
A1 Chavdarova, Lidia
A1 Hoffmann, Martha
A1 Kobe, Carsten
A1 Malkowski, Bogdan
A1 Montravers, Françoise
A1 Kurch, Lars
A1 Georgi, Thomas
A1 Dietlein, Markus
A1 Wallace, W Hamish
A1 Karlen, Jonas
A1 Fernández-Teijeiro, Ana
A1 Cepelova, Michaela
A1 Wilson, Lorrain
A1 Bergstraesser, Eva
A1 Sabri, Osama
A1 Mauz-Körholz, Christine
A1 Körholz, Dieter
A1 Hasenclever, Dirk
K1 Ensayo clínico controlado aleatorio
K1 Enfermedad de Hodgkin
K1 Sistema musculoesquelético
K1 Estudio multicéntrico
K1 Brown adipose tissue
K1 Chemotherapy
K1 Positron emission tomography
K1 Lymphomas
K1 Pediatrics
K1 Hodgkin lymphoma
K1 Lymph nodes
K1 Thymus
AB PurposeThe five point Deauville (D) scale is widely used to assess interim PET metabolic response to chemotherapy in Hodgkin lymphoma (HL) patients. An International Validation Study reported good concordance among reviewers in ABVD treated advanced stage HL patients for the binary discrimination between score D1,2,3 and score D4,5. Inter-reader reliability of the whole scale is not well characterised.METHODSFive international expert readers scored 100 interim PET/CT scans from paediatric HL patients. Scans were acquired in 51 European hospitals after two courses of OEPA chemotherapy (according to the EuroNet-PHL-C1 study). Images were interpreted in direct comparison with staging PET/CTs.RESULTSThe probability that two random readers concord on the five point D score of a random case is only 42% (global kappa = 0.24). Aggregating to a three point scale D1,2 vs. D3 vs. D4,5 improves concordance to 60% (kappa = 0.34). Concordance if one of two readers assigns a given score is 70% for score D1,2 only 36% for score D3 and 64% for D4,5. Concordance for the binary decisions D1,2 vs. D3,4,5 is 67% and 86% for D1,2,3 vs D4,5 (kappa = 0.36 resp. 0.56). If one reader assigns D1,2,3 concordance probability is 92%, but only 64% if D4,5 is called. Discrepancies occur mainly in mediastinum, neck and skeleton.CONCLUSIONInter-reader reliability of the five point D-scale is poor in this interobserver analysis of paediatric patients who underwent OEPA. Inter-reader variability is maximal in cases assigned to D2 or D3. The binary distinction D1,2,3 versus D4,5 is the most reliable criterion for clinical decision making.
PB Public Library of Science
YR 2016
FD 2016-03-10
LK http://hdl.handle.net/10668/2738
UL http://hdl.handle.net/10668/2738
LA en
NO Kluge R, Chavdarova L, Hoffmann M, Kobe C, Malkowski B, Montravers F, et al. Inter-Reader Reliability of Early FDG-PET/CT Response Assessment Using the Deauville Scale after 2 Cycles of Intensive Chemotherapy (OEPA) in Hodgkin's Lymphoma. PLoS ONE. 2016; 11(3):e0149072
NO Journal Article;
DS RISalud
RD Apr 19, 2025