RT Journal Article
T1 Role of the Holoenzyme PP1-SPN in the Dephosphorylation of the RB Family of Tumor Suppressors During Cell Cycle
A1 Verdugo-Sivianes, Eva M.
A1 Carnero, Amancio
K1 RB family proteins
K1 Pocket proteins
K1 Cell cycle
K1 Phosphatase PP1
K1 Spinophilin
K1 PPP1R9B
K1 Cancer
K1 Tumorigenesis
K1 Retinoblastoma protein
K1 Phosphorylation
K1 Catalytic subunit
K1 Cyclin-dependent kinases
K1 Stem cell
K1 Breast cancer
K1 Holoenzymes
K1 Proteína fosfatasa 1
K1 Neoplasias
K1 Carcinogénesis
K1 Proteína de retinoblastoma
K1 Fosforilación
K1 Dominio catalítico
K1 Quinasas ciclina-dependientes
K1 Células madre
K1 Neoplasias de la mama
K1 Holoenzimas
AB Cell cycle progression is highly regulated by modulating the phosphorylation status of the retinoblastoma protein (pRB) and the other two members of the RB family, p107 and p130. This process is controlled by a balance in the action of kinases, such as the complexes formed by cyclin-dependent kinases (CDKs) and cyclins, and phosphatases, mainly the protein phosphatase 1 (PP1). However, while the phosphorylation of the RB family has been largely studied, its dephosphorylation is less known. Phosphatases are holoenzymes formed by a catalytic subunit and a regulatory protein with substrate specificity. Recently, the PP1-Spinophilin (SPN) holoenzyme has been described as the main phosphatase responsible for the dephosphorylation of RB proteins during the G0/G1 transition and at the end of G1. Moreover, SPN has been described as a tumor suppressor dependent on PP1 in lung and breast tumors, where it promotes tumorigenesis by increasing the cancer stem cell pool. Therefore, a connection between the cell cycle and stem cell biology has also been proposed via SPN/PP1/RB proteins.
PB MDPI
YR 2021
FD 2021-05-06
LK http://hdl.handle.net/10668/4331
UL http://hdl.handle.net/10668/4331
LA en
NO Verdugo-Sivianes EM, Carnero A. Role of the Holoenzyme PP1-SPN in the Dephosphorylation of the RB Family of Tumor Suppressors During Cell Cycle. Cancers. 2021 May 6;13(9):2226
DS RISalud
RD Apr 7, 2025