RT Journal Article T1 Extrahypothalamic Control of Energy Balance and Its Connection with Reproduction: Roles of the Amygdala. A1 Pineda, Rafael A1 Torres, Encarnacion A1 Tena-Sempere, Manuel K1 amygdala K1 body weight K1 energy balance K1 estrogens K1 food intake K1 kisspeptins K1 metabolism K1 neuropeptides AB Body energy and metabolic homeostasis are exquisitely controlled by multiple, often overlapping regulatory mechanisms, which permit the tight adjustment between fuel reserves, internal needs, and environmental (e.g., nutritional) conditions. As such, this function is sensitive to and closely connected with other relevant bodily systems, including reproduction and gonadal function. The aim of this mini-review article is to summarize the most salient experimental data supporting a role of the amygdala as a key brain region for emotional learning and behavior, including reward processing, in the physiological control of feeding and energy balance. In particular, a major focus will be placed on the putative interplay between reproductive signals and amygdala pathways, as it pertains to the control of metabolism, as complementary, extrahypothalamic circuit for the integral control of energy balance and gonadal function. SN 2218-1989 YR 2021 FD 2021-12-03 LK https://hdl.handle.net/10668/25631 UL https://hdl.handle.net/10668/25631 LA en DS RISalud RD Apr 10, 2025