RT Journal Article
T1 Pneumocystis primary infection in non-immunosuppressed infants in Lima, Peru.
A1 Ochoa, Theresa J
A1 Bustamante, Beatriz
A1 Garcia, Coralith
A1 Neyra, Edgar
A1 Mendoza, Karina
A1 Calderón, Enrique J
A1 Le Gal, Solene
A1 Miller, Robert F
A1 Ponce, Carolina A
A1 Nevez, Gilles
A1 Vargas, Sergio L
K1 Infants
K1 Peru
K1 Pneumocystis jirovecii,Pulmonary colonization
K1 Primary infection
AB To provide original data on Pneumocystis primary infection in non-immunosuppressed infants from Peru. A cross sectional study was performed. Infants less than seven months old, without any underlying medical conditions attending the "well baby" outpatient clinic at one hospital in Lima, Peru were prospectively enrolled during a 15-month period from November 2016 to February 2018. All had a nasopharyngeal aspirate (NPA) for detection of P. jirovecii DNA using a PCR assay, regardless of respiratory symptoms. P. jirovecii DNA detection was considered to represent pulmonary colonization contemporaneous with Pneumocystis primary infection. Associations between infants' clinical and demographic characteristics and results of P. jirovecii DNA detection were analyzed. P. jirovecii DNA was detected in 45 of 146 infants (30.8%) and detection was not associated with concurrent respiratory symptoms in 40 of 45 infants. Infants with P. jirovecii had a lower mean age when compared to infants not colonized (p  Pneumocystis primary infection in this single site in Lima, Peru, was most frequently observed in 2-3-month-old infants, in winter and spring seasons, and with higher detection rates being associated with household conditions favoring close inter-individual contacts and potential transmission of P. jirovecii.
YR 2021
FD 2021-09-04
LK http://hdl.handle.net/10668/22401
UL http://hdl.handle.net/10668/22401
LA en
DS RISalud
RD Apr 9, 2025