RT Journal Article
T1 Inappropriate antibiotic use in the COVID-19 era: Factors associated with inappropriate prescribing and secondary complications. Analysis of the registry SEMI-COVID.
A1 Calderon-Parra, Jorge
A1 Muiño-Miguez, Antonio
A1 Bendala-Estrada, Alejandro D
A1 Ramos-Martinez, Antonio
A1 Muñez-Rubio, Elena
A1 Fernandez-Carracedo, Eduardo
A1 Tejada-Montes, Javier
A1 Rubio-Rivas, Manuel
A1 Arnalich-Fernandez, Francisco
A1 Beato-Perez, Jose Luis
A1 Garcia-Bruñen, Jose Miguel
A1 Del-Corral-Beamonte, Esther
A1 Pesqueira-Fontan, Paula Maria
A1 Carmona, Maria Del Mar
A1 Fernandez-Madera-Martinez, Rosa
A1 Gonzalez-Garcia, Andres
A1 Salazar-Mosteiro, Cristina
A1 Tuñon-de-Almeida, Carlota
A1 Gonzalez-Moraleja, Julio
A1 Deodati, Francesco
A1 Martin-Escalante, Maria Dolores
A1 Asensio-Tomas, Maria Luisa
A1 Gomez-Huelgas, Ricardo
A1 Casas-Rojo, Jose Manuel
A1 Millan Nuñez-Cortes, Jesus
K1 Anti-Bacterial Agents
K1 C-Reactive Protein
K1 COVID-19
K1 Comorbidity
K1 Cough
AB Most patients with COVID-19 receive antibiotics despite the fact that bacterial co-infections are rare. This can lead to increased complications, including antibacterial resistance. We aim to analyze risk factors for inappropriate antibiotic prescription in these patients and describe possible complications arising from their use. The SEMI-COVID-19 Registry is a multicenter, retrospective patient cohort. Patients with antibiotic were divided into two groups according to appropriate or inappropriate prescription, depending on whether the patient fulfill any criteria for its use. Comparison was made by means of multilevel logistic regression analysis. Possible complications of antibiotic use were also identified. Out of 13,932 patients, 3047 (21.6%) were prescribed no antibiotics, 6116 (43.9%) were appropriately prescribed antibiotics, and 4769 (34.2%) were inappropriately prescribed antibiotics. The following were independent factors of inappropriate prescription: February-March 2020 admission (OR 1.54, 95%CI 1.18-2.00), age (OR 0.98, 95%CI 0.97-0.99), absence of comorbidity (OR 1.43, 95%CI 1.05-1.94), dry cough (OR 2.51, 95%CI 1.94-3.26), fever (OR 1.33, 95%CI 1.13-1.56), dyspnea (OR 1.31, 95%CI 1.04-1.69), flu-like symptoms (OR 2.70, 95%CI 1.75-4.17), and elevated C-reactive protein levels (OR 1.01 for each mg/L increase, 95% CI 1.00-1.01). Adverse drug reactions were more frequent in patients who received ANTIBIOTIC (4.9% vs 2.7%, p  The inappropriate use of antibiotics was very frequent in COVID-19 patients and entailed an increased risk of adverse reactions. It is crucial to define criteria for their use in these patients. Knowledge of the factors associated with inappropriate prescribing can be helpful.
PB Public Library of Science
YR 2021
FD 2021-05-11
LK http://hdl.handle.net/10668/17779
UL http://hdl.handle.net/10668/17779
LA en
NO Calderón-Parra J, Muiño-Miguez A, Bendala-Estrada AD, Ramos-Martínez A, Muñez-Rubio E, Fernández Carracedo E, et al. Inappropriate antibiotic use in the COVID-19 era: Factors associated with inappropriate prescribing and secondary complications. Analysis of the registry SEMI-COVID. PLoS One. 2021 May 11;16(5):e0251340
DS RISalud
RD Apr 11, 2025