RT Journal Article
T1 Vascular patterns provide therapeutic targets in aggressive neuroblastic tumors.
A1 Tadeo, Irene
A1 Bueno, Gloria
A1 Berbegall, Ana P
A1 Fernández-Carrobles, M Milagro
A1 Castel, Victoria
A1 García-Rojo, Marcial
A1 Navarro, Samuel
A1 Noguera, Rosa
K1 blood vessels
K1 capillaries
K1 extracellular matrix
K1 neuroblastoma
K1 sinusoids
AB Angiogenesis is essential for tumor growth and metastasis, nevertheless, in NB, results between different studies on angiogenesis have yielded contradictory results. An image analysis tool was developed to characterize the density, size and shape of total blood vessels and vascular segments in 458 primary neuroblastic tumors contained in tissue microarrays. The results were correlated with clinical and biological features of known prognostic value and with risk of progression to establish histological vascular patterns associated with different degrees of malignancy. Total blood vessels were larger, more abundant and more irregularly-shaped in tumors of patients with associated poor prognostic factors than in the favorable cohort. Tumor capillaries were less abundant and sinusoids more abundant in the patient cohort with unfavorable prognostic factors. Additionally, size of post-capillaries & metarterioles as well as higher sinusoid density can be included as predictive factors for survival. These patterns may therefore help to provide more accurate pre-treatment risk stratification, and could provide candidate targets for novel therapies.
YR 2016
FD 2016
LK http://hdl.handle.net/10668/9871
UL http://hdl.handle.net/10668/9871
LA en
DS RISalud
RD Apr 6, 2025