RT Journal Article
T1 Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming
A1 Sanchez-Castro, E. Eduardo
A1 Pajuelo-Reyes, Cecilia
A1 Tejedo, Rebeca
A1 Soria-Juan, Bárbara
A1 Tapia-Limonchi, Rafael
A1 Andreu, Etelvina
A1 Hitos, Ana B.
A1 Martin, Franz
A1 Cahuana, Gladys M.
A1 Guerra-Duarte, Clara
A1 Silva de Assis, Thamyres C.
A1 Bedoya, Francisco J.
A1 Soria, Bernat
A1 Chávez-Olórtegui, Carlos
A1 Tejedo, Juan R.
K1 Advanced therapy medicinal products
K1 Mesenchymal stromal cells
K1 Snakebite
K1 Envenoming
K1 Muscle regeneration
K1 Células madre mesenquimatosas
K1 Mordeduras de serpientes
K1 Envenenamiento
AB Snakebite envenoming is a global neglected disease with an incidence of up to 2.7 million new cases every year. Although antivenoms are so-far the most effective treatment to reverse the acute systemic effects induced by snakebite envenoming, they have a limited therapeutic potential, being unable to completely neutralize the local venom effects. Local damage, such as dermonecrosis and myonecrosis, can lead to permanent sequelae with physical, social, and psychological implications. The strong inflammatory process induced by snake venoms is associated with poor tissue regeneration, in particular the lack of or reduced skeletal muscle regeneration. Mesenchymal stromal cells (MSCs)-based therapies have shown both anti-inflammatory and pro-regenerative properties. We postulate that using allogeneic MSCs or their cell-free products can induce skeletal muscle regeneration in snakebite victims, improving all the three steps of the skeletal muscle regeneration process, mainly by anti-inflammatory activity, paracrine effects, neovascularization induction, and inhibition of tissue damage, instrumental for microenvironment remodeling and regeneration. Since snakebite envenoming occurs mainly in areas with poor healthcare, we enlist the principles and potential of MSCs-based therapies and discuss regulatory issues, good manufacturing practices, transportation, storage, and related-procedures that could allow the administration of these therapies, looking forward to a safe and cost-effective treatment for a so far unsolved and neglected health problem.
PB Frontiers
YR 2021
FD 2021-02-03
LK http://hdl.handle.net/10668/3616
UL http://hdl.handle.net/10668/3616
LA en
NO Sanchez-Castro EE, Pajuelo-Reyes C, Tejedo R, Soria-Juan B, Tapia-Limonchi R, Andreu E, et al. Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming. Front Immunol. 2021 Feb 3;11:609961.
DS RISalud
RD Apr 6, 2025