RT Journal Article
T1 Clinical Value of Inflammatory and Neurotrophic Biomarkers in Bipolar Disorder: A Systematic Review and Meta-Analysis.
A1 Vega-Nuñez, Amanda
A1 Gomez-Sanchez-Lafuente, Carlos
A1 Mayoral-Cleries, Fermin
A1 Bordallo, Antonio
A1 Rodriguez-de-Fonseca, Fernando
A1 Suarez, Juan
A1 Guzman-Parra, Jose
K1 BDNF
K1 Biomarker
K1 Bipolar disorder
K1 Clinical factors
K1 Cytokines
K1 Depression
K1 Mania
K1 Meta-analysis
K1 Neurotrophins
K1 Systematic review
AB Bipolar disorder (BD) is a multifactorial chronic psychiatric disease highly defined by genetic, clinical, environmental and social risk factors. The present systematic review and meta-analysis aimed to examine the relationship between inflammatory and neurotrophic factors and clinical, social and environmental factors involved in the development and the characterization of BD. Web of Science, PubMed, PsycINFO, Scopus and Science Direct were searched by two independent reviewers. The systematic review was registered in PROSPERO (CRD42020180626). A total of 51 studies with 4547 patients with a diagnosis of BD were selected for systematic review. Among them, 18 articles were included for meta-analysis. The study found some evidence of associations between BDNF and/or inflammatory factors and different stressors and functional and cognitive impairment, but limitations prevented firm conclusions. The main finding of the meta-analysis was a negative correlation between circulating levels of BDNF and depression severity score (standardized mean difference = -0.22, Confidence Interval 95% = -0.38, -0.05, p = 0.01). Evidence indicates that BDNF has a role in the depressive component of BD. However, the poor consistency found for other inflammatory mediators clearly indicates that highly controlled studies are needed to identity precise biomarkers of this disorder.
PB MDPI
SN 2227-9059
YR 2022
FD 2022-06-09
LK http://hdl.handle.net/10668/20834
UL http://hdl.handle.net/10668/20834
LA en
NO Vega-Núñez A, Gómez-Sánchez-Lafuente C, Mayoral-Cleries F, Bordallo A, Rodríguez de Fonseca F, Suárez J, et al. Clinical Value of Inflammatory and Neurotrophic Biomarkers in Bipolar Disorder: A Systematic Review and Meta-Analysis. Biomedicines. 2022 Jun 9;10(6):1368
NO This research was funded by Atención Primaria, Cronicidad y Promoción de la Salud: Red de Investigación en Atención Primaria de Adicciones (RIAPAd), Instituto de Salud Carlos III (ISCIII), Ministerio de Ciencia e Innovación and European Regional Development Funds-European Union (ERDF-EU), grant number RD21/0009/0003; ISCIII, ERDF-EU, grant number PI19/01577; Ministerio de Sanidad, Delegación de Gobierno para el Plan Nacional sobre Drogas, grant numbers PND2019/040; and Consejería de Salud y Familia, Junta de Andalucía, grant numbers RIC-0111-2019. AV-N (CM19/00025) and CG-S-L (CM19/00240) hold “Rio Hortega” research contracts from the National System of Health, ISCIII, ERDF-EU. FM-C and JG-Ph have received funding from the Andalusia Government in the grants for human resources reinforcement in research activity (Acción A de intensificación 2019 and Acción B de refuerzos de larga duración 2014).
DS RISalud
RD Apr 6, 2025