TY - JOUR AU - Decara, Juan M AU - Vazquez-Villa, Henar AU - Brea, Jose AU - Alonso, Monica AU - Srivastava, Raj Kamal AU - Orio, Laura AU - Alen, Francisco AU - Suarez, Juan AU - Baixeras, Elena AU - Garcia-Carceles, Javier AU - Escobar-Peña, Andrea AU - Lutz, Beat AU - Rodriguez, Ramon AU - Codesido, Eva AU - Garcia-Ladona, F Javier AU - Bennett, Teresa A AU - Ballesteros, Juan A AU - Cruces, Jacobo AU - Loza, Maria I AU - Benhamu, Bellinda AU - Rodriguez-de-Fonseca, Fernando AU - Lopez-Rodriguez, Maria L PY - 2022 DO - 10.1021/acs.jmedchem.1c01842 UR - http://hdl.handle.net/10668/22590 T2 - Journal of medicinal chemistry AB - Peptidic agonists of the glucagon-like peptide-1 receptor (GLP-1R) have gained a prominent role in the therapy of type-2 diabetes and are being considered for reducing food intake in obesity. Potential advantages of small molecules acting as positive... LA - en PB - American Chemical Society KW - Eating KW - Insulin Secretion KW - Glucose KW - Administration, Oral KW - Animals KW - Diabetes Mellitus, Type 2 KW - Glucagon-Like Peptide-1 Receptor KW - Obesity KW - Peptides TI - Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for "Diabesity". TY - research article VL - 65 ER -