RT Journal Article
T1 Association analysis of urotensin II gene (UTS2) and flanking regions with biochemical parameters related to insulin resistance.
A1 Sáez, María E
A1 Smani, Tarik
A1 Ramírez-Lorca, Reposo
A1 Díaz, Ignacio
A1 Serrano-Ríos, Manuel
A1 Ruiz, Agustín
A1 Ordoñez, Antonio
K1 Urotensinas
K1 Resistencia a la insulina
K1 Polimorfismo genético
AB Background. Urotensin II (UII) is a potent vasoconstrictor peptide, which signals through a G-protein coupled receptor (GPCR) known as GPR14 or urotensin receptor (UTR). UII exerts a broad spectrum of actions in several systems such as vascular cell, heart muscle or pancreas, where it inhibits insulin release. Objective. Given the reported role of UII in insulin secretion, we have performed a genetic association analysis of the UTS2 gene and flanking regions with biochemical parameters related to insulin resistance (fasting glucose, glucose 2 hours after a glucose overload, fasting insulin and insulin resistance estimated as HOMA). Results and Conclusions. We have identified several polymorphisms associated with the analysed clinical traits, not only at the UTS2 gene, but also in thePER3 gene, located upstream from UTS2. Our results are compatible with a role for UII in glucose homeostasis and diabetes although we cannot rule out the possibility that PER3 gene may underlie the reported associations.
PB PLoS
YR 2011
FD 2011-04-29
LK http://hdl.handle.net/10668/337
UL http://hdl.handle.net/10668/337
LA en
NO Sáez ME, Smani T, Ramírez-Lorca R, Díaz I, Serrano-Ríos M, Ruiz A, et al. Association Analysis of Urotensin II Gene (UTS2) and Flanking Regions with Biochemical Parameters Related to Insulin Resistance.PLoS ONE 2011; 6(4): e19327
DS RISalud
RD Apr 6, 2025