TY  - JOUR
AU  - Domingo-Prim, Judit
AU  - Endara-Coll, Martin
AU  - Bonath, Franziska
AU  - Jimeno, Sonia
AU  - Prados-Carvajal, Rosario
AU  - Friedländer, Marc R
AU  - Huertas, Pablo
AU  - Visa, Neus
PY  - 2019
DO  - 10.1038/s41467-019-10153-9
UR  - http://hdl.handle.net/10668/13957
T2  - Nature communications
AB  - The exosome is a ribonucleolytic complex that plays important roles in RNA metabolism. Here we show that the exosome is necessary for the repair of DNA double-strand breaks (DSBs) in human cells and that RNA clearance is an essential step in...
LA  - en
KW  - DNA
KW  - DNA Breaks, Double-Stranded
KW  - Exoribonucleases
KW  - Exosome Multienzyme Ribonuclease Complex
KW  - Exosomes
KW  - Gene Knockdown Techniques
KW  - HeLa Cells
KW  - Homologous Recombination
KW  - Humans
KW  - RNA, Long Noncoding
KW  - RNA, Small Interfering
KW  - Rad51 Recombinase
KW  - Replication Protein A
KW  - Ribonuclease H
TI  - EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks.
TY  - research article
VL  - 10
ER  -