RT Journal Article
T1 Characterization of non-linear mechanical behavior of the cornea
A1 Ashofteh Yazdi, A.
A1 Melchor, J.
A1 Torres, J.
A1 Faris, I.
A1 Callejas, A.
A1 Gonzalez-Andrades, M.
A1 Rus, G.
K1 Animals
K1 Biomechanical Phenomena
K1 Nonlinear Dynamics
K1 Swine
K1 Cornea
K1 Animales
K1 Fenómenos biomecánicos
K1 Dinámicas no lineales
K1 Porcinos
K1 Córnea
AB The objective of this study was to evaluate which hyperelastic model could best describe the non-linear mechanical behavior of the cornea, in order to characterize the capability of the non-linear model parameters to discriminate structural changes in a damaged cornea. Porcine corneas were used, establishing two different groups: control (non-treated) and NaOH-treated (damaged) corneas (n = 8). NaOH causes a chemical burn to the corneal tissue, simulating a disease associated to structural damage of the stromal layer. Quasi-static uniaxial tensile tests were performed in nasal-temporal direction immediately after preparing corneal strips from the two groups. Three non-linear hyperelastic models (i.e. Hamilton-Zabolotskaya model, Ogden model and Mooney-Rivlin model) were fitted to the stress-strain curves obtained in the tensile tests and statistically compared. The corneas from the two groups showed a non-linear mechanical behavior that was best described by the Hamilton-Zabolotskaya model, obtaining the highest coefficient of determination (R2 > 0.95). Moreover, Hamilton-Zabolotskaya model showed the highest discriminative capability of the non-linear model parameter (Parameter A) for the tissue structural changes between the two sample groups (p = 0.0005). The present work determines the best hyperelastic model with the highest discriminative capability in description of the non-linear mechanical behavior of the cornea.
PB Springer Nature
YR 2020
FD 2020-07-14
LK http://hdl.handle.net/10668/3510
UL http://hdl.handle.net/10668/3510
LA en
NO Ashofteh Yazdi A, Melchor J, Torres J, Faris I, Callejas A, Gonzalez-Andrades M, et al. Characterization of non-linear mechanical behavior of the cornea. Sci Rep. 2020 Jul 14;10(1):11549.
DS RISalud
RD Apr 9, 2025