RT Journal Article
T1 Persistent changes in exploration and hyperactivity coexist with cognitive impairment in mice withdrawn from chronic cocaine.
A1 Mañas-Padilla, M Carmen
A1 Ávila-Gámiz, Fabiola
A1 Gil-Rodríguez, Sara
A1 Ladrón de Guevara-Miranda, David
A1 Rodríguez de Fonseca, Fernando
A1 Santín, Luis J
A1 Castilla-Ortega, Estela
K1 Anxiety
K1 Elevated plus maze
K1 Forced swimming
K1 Place recognition memory
K1 Spatial working memory
AB Repeated cocaine exposure induces lasting neurobehavioral adaptations such as cognitive decline in animal models. However, persistent changes in spontaneous -unconditioned- motor and exploratory responses are scarcely reported. In this study, mice were administered with cocaine (20 mg/kg/day) or vehicle for 12 consecutive days. After 24 days of drug abstinence, a behavioral assessment was carried out in drug-free conditions and in unfamiliar environments (i.e. no cocaine-associated cues were presented). The cocaine-withdrawn mice showed cognitive deficits in spontaneous alternation behavior and place recognition memory. Importantly, they also displayed hyperlocomotion, increased rearing activity and altered exploratory patterns in different tasks. In the forced swimming test, they were more active (struggled/climbed more) when trying to escape from the water albeit showing normal immobility behavior. In conclusion, in addition to cognitive deficits, chronic cocaine in rodents may induce long-lasting alterations in exploratory activity and psychomotor activation that are triggered even in absence of drug-related stimuli.
YR 2021
FD 2021-07-30
LK https://hdl.handle.net/10668/24529
UL https://hdl.handle.net/10668/24529
LA en
DS RISalud
RD Apr 6, 2025