RT Journal Article
T1 Plant foods, dietary fibre and risk of ischaemic heart disease in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
A1 Perez-Cornago, Aurora
A1 Crowe, Francesca L
A1 Appleby, Paul N
A1 Bradbury, Kathryn E
A1 Wood, Angela M
A1 Jakobsen, Marianne Uhre
A1 Johnson, Laura
A1 Sacerdote, Carlotta
A1 Steur, Marinka
A1 Weiderpass, Elisabete
A1 Würtz, Anne Mette L
A1 Kühn, Tilman
A1 Katzke, Verena
A1 Trichopoulou, Antonia
A1 Karakatsani, Anna
A1 La Vecchia, Carlo
A1 Masala, Giovanna
A1 Tumino, Rosario
A1 Panico, Salvatore
A1 Sluijs, Ivonne
A1 Skeie, Guri
A1 Imaz, Liher
A1 Petrova, Dafina
A1 Quirós, J Ramón
A1 Yohar, Sandra Milena Colorado
A1 Jakszyn, Paula
A1 Melander, Olle
A1 Sonestedt, Emily
A1 Andersson, Jonas
A1 Wennberg, Maria
A1 Aune, Dagfinn
A1 Riboli, Elio
A1 Schulze, Matthias B
A1 di Angelantonio, Emanuele
A1 Wareham, Nicholas J
A1 Danesh, John
A1 Forouhi, Nita G
A1 Butterworth, Adam S
A1 Key, Timothy J
K1 Fruit
K1 coronary heart disease
K1 legumes
K1 nuts
K1 seeds
K1 vegetables
AB Epidemiological evidence indicates that diets rich in plant foods are associated with a lower risk of ischaemic heart disease (IHD), but there is sparse information on fruit and vegetable subtypes and sources of dietary fibre. This study examined the associations of major plant foods, their subtypes and dietary fibre with risk of IHD in the European Prospective Investigation into Cancer and Nutrition (EPIC). We conducted a prospective analysis of 490 311 men and women without a history of myocardial infarction or stroke at recruitment (12.6 years of follow-up, n cases = 8504), in 10 European countries. Dietary intake was assessed using validated questionnaires, calibrated with 24-h recalls. Multivariable Cox regressions were used to estimate hazard ratios (HR) of IHD. There was a lower risk of IHD with a higher intake of fruit and vegetables combined [HR per 200 g/day higher intake 0.94, 95% confidence interval (CI): 0.90-0.99, P-trend = 0.009], and with total fruits (per 100 g/day 0.97, 0.95-1.00, P-trend = 0.021). There was no evidence for a reduced risk for fruit subtypes, except for bananas. Risk was lower with higher intakes of nuts and seeds (per 10 g/day 0.90, 0.82-0.98, P-trend = 0.020), total fibre (per 10 g/day 0.91, 0.85-0.98, P-trend = 0.015), fruit and vegetable fibre (per 4 g/day 0.95, 0.91-0.99, P-trend = 0.022) and fruit fibre (per 2 g/day 0.97, 0.95-1.00, P-trend = 0.045). No associations were observed between vegetables, vegetables subtypes, legumes, cereals and IHD risk. In this large prospective study, we found some small inverse associations between plant foods and IHD risk, with fruit and vegetables combined being the most strongly inversely associated with risk. Whether these small associations are causal remains unclear.
YR 2021
FD 2021
LK http://hdl.handle.net/10668/16680
UL http://hdl.handle.net/10668/16680
LA en
DS RISalud
RD Apr 11, 2025