RT Journal Article
T1 Clonal genetic evolution at relapse of favorable-risk acute myeloid leukemia with NPM1 mutation is associated with phenotypic changes and worse outcomes.
A1 Martinez-Losada, Carmen
A1 Serrano-Lopez, Juana
A1 Serrano-Lopez, Josefina
A1 Noguera, Nelida I
A1 Garza, Eduardo
A1 Piredda, Liliana
A1 Lavorgna, Serena
A1 Consalvo, Maria Antonietta Irno
A1 Ottone, Tiziana
A1 Alfonso, Valentina
A1 Peinado, Juan Ramon
A1 Garcia-Ortiz, Maria Victoria
A1 Morales-Ruiz, Teresa
A1 Jerez, Andres
A1 Hurtado, Ana Maria
A1 Montesinos, Pau
A1 Cervera, Jose
A1 Such, Esperanza
A1 Ibañez, Marian
A1 Sempere, Amparo
A1 Sanz, Miguel Angel
A1 Lo-Coco, Francesco
A1 Sanchez-Garcia, Joaquin
K1 Biomarkers, Tumor
K1 Clonal Evolution
K1 DNA Mutational Analysis
K1 Genetic Association Studies
K1 Genome-Wide Association Study
AB Acute myeloid leukemia (AML) is a dynamic disease caused by accumulating, somatically acquired driver mutations generating branching competing clones.1 In favorable-risk AML, high resolution genomic profiling by single nucleotide polymorphism array analysis of paired diagnostic-relapse NPM1mut and CBF AML samples revealed increased genomic complexity at relapse butmost patients retained founding mutations.2,3 Furthermore, it has been extensively reported that phe notypic changes are commonly found at relapse in AML patients. It seems plausible that clonal evolution could bereflected in the phenotypic shifts of AML blast cells found at relapse, although the correlation with genetic clonal evolution has not been established
PB Fondazione Ferrata Storti
YR 2018
FD 2018-04-05
LK http://hdl.handle.net/10668/12316
UL http://hdl.handle.net/10668/12316
LA en
NO Martínez-Losada C, Serrano-López J, Serrano-López J, Noguera NI, Garza E, Piredda L, et al. Clonal genetic evolution at relapse of favorable-risk acute myeloid leukemia with NPM1 mutation is associated with phenotypic changes and worse outcomes. Haematologica. 2018 Sep;103(9):e400-e403
DS RISalud
RD Apr 6, 2025