RT Journal Article T1 International comparison of trends in patients commencing renal replacement therapy by primary renal disease. A1 Stel, Vianda S A1 Awadhpersad, Ryan A1 Pippias, Maria A1 Ferrer-Alamar, Manuel A1 Finne, Patrik A1 Fraser, Simon D A1 Heaf, James G A1 Hemmelder, Marc H A1 Martínez-Castelao, Alberto A1 de Meester, Johan A1 Palsson, Runolfur A1 Prischl, Friedrich C A1 Segelmark, Mårten A1 Traynor, Jamie P A1 Santamaria, Rafael A1 Reisaeter, Anna Varberg A1 Massy, Ziad A A1 Jager, Kitty J K1 Diabetes mellitus K1 Hypertension K1 Primary renal disease K1 Renal replacement therapy K1 Trends K1 Worldwide AB To examine international time trends in the incidence of renal replacement therapy (RRT) for end-stage renal disease (ESRD) by primary renal disease (PRD). Renal registries reporting on patients starting RRT per million population for ESRD by PRD from 2005 to 2014, were identified by internet search and literature review. The average annual percentage change (AAPC) with a 95% confidence interval (CI) of the time trends was computed using Joinpoint regression. There was a significant decrease in the incidence of RRT for ESRD due to diabetes mellitus (DM) in Europe (AAPC = -0.9; 95%CI -1.3; -0.5) and to hypertension/renal vascular disease (HT/RVD) in Australia (AAPC = -1.8; 95%CI -3.3; -0.3), Canada (AAPC = -2.9; 95%CI -4.4; -1.5) and Europe (AAPC = -1.1; 95%CI -2.1; -0.0). A decrease or stabilization was observed for glomerulonephritis in all regions and for autosomal dominant polycystic kidney disease (ADPKD) in all regions except for Malaysia and the Republic of Korea. An increase of 5.2-16.3% was observed for DM, HT/RVD and ADPKD in Malaysia and the Republic of Korea. Large international differences exist in the trends in incidence of RRT by primary renal disease. Mapping of these international trends is the first step in defining the causes and successful preventative measures of CKD. PB Wiley YR 2018 FD 2018-11-13 LK http://hdl.handle.net/10668/13211 UL http://hdl.handle.net/10668/13211 LA en NO Stel VS, Awadhpersad R, Pippias M, Ferrer-Alamar M, Finne P, Fraser SD, et al. International comparison of trends in patients commencing renal replacement therapy by primary renal disease. Nephrology (Carlton). 2019 Oct;24(10):1064-1076 DS RISalud RD Apr 6, 2025