%0 Journal Article
%A Vila-Farres, Xavier
%A Parra-Millan, Raquel
%A Sanchez-Encinales, Viviana
%A Varese, Monica
%A Ayerbe-Algaba, Rafael
%A Bayo, Nuria
%A Guardiola, Salvador
%A Pachon-Ibañez, María Eugenia
%A Kotev, Martin
%A Garcia, Jesus
%A Teixido, Meritxell
%A Vila, Jordi
%A Pachon, Jeronimo
%A Giralt, Ernest
%A Smani, Younes
%T Combating virulence of Gram-negative bacilli by OmpA inhibition.
%D 2017
%U http://hdl.handle.net/10668/11756
%X Preventing the adhesion of pathogens to host cells provides an innovative approach to tackling multidrug-resistant bacteria. In this regard, the identification of outer membrane protein A (OmpA) as a key bacterial virulence factor has been a major breakthrough. The use of virtual screening helped us to identify a cyclic hexapeptide AOA-2 that inhibits the adhesion of Acinetobacter baumannii, Pseudomonas aeruginosa and Escherichia coli to host cells and the formation of biofilm, thereby preventing the development of infection in vitro and in a murine sepsis peritoneal model. Inhibition of OmpA offers a strategy as monotherapy to address the urgent need for treatments for infections caused by Gram-negative bacilli.
%K Drug discovery and development
%K Pathogens
%~