RT Journal Article
T1 Plasma Levels of Endocannabinoids and Their Analogues Are Related to Specific Fecal Bacterial Genera in Young Adults: Role in Gut Barrier Integrity.
A1 Ortiz-Alvarez, Lourdes
A1 Xu, Huiwen
A1 Di, Xinyu
A1 Kohler, Isabelle
A1 Osuna-Prieto, Francisco J
A1 Acosta, Francisco M
A1 Vilchez-Vargas, Ramiro
A1 Link, Alexander
A1 Plaza-Diaz, Julio
A1 van der Stelt, Mario
A1 Hankemeier, Thomas
A1 Clemente-Postigo, Mercedes
A1 Tinahones, Francisco J
A1 Gil, Angel
A1 Rensen, Patrick C N
A1 Ruiz, Jonatan R
A1 Martinez-Tellez, Borja
K1 Endocannabinoid system
K1 Gastrointestinal microbiome
K1 Gut barrier
K1 Inflammation
K1 Short-chain fatty acids
AB To investigate the association of plasma levels of endocannabinoids with fecal microbiota. Plasma levels of endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), as well as their eleven analogues, and arachidonic acid (AA), were measured using liquid chromatography-tandem mass spectrometry in 92 young adults. DNA extracted from stool samples was analyzed using 16S rRNA gene sequencing. Lipopolysaccharide levels were measured in plasma samples. Plasma levels of endocannabinoids and their analogues were not related to beta or alpha diversity indexes. Plasma levels of AEA and related N-acylethanolamines correlated positively with the relative abundance of Faecalibacterium genus (all rho ≥ 0.26, p ≤ 0.012) and Akkermansia genus (all rho ≥ 0.22, p ≤ 0.036), and negatively with the relative abundance of Bilophila genus (all rho ≤ -0.23, p ≤ 0.031). Moreover, plasma levels of 2-AG and other acylglycerols correlated positively with the relative abundance of Parasutterella (all rho ≥ 0.24, p ≤ 0.020) and Odoribacter genera (all rho ≥ 0.27, p ≤ 0.011), and negatively with the relative abundance of Prevotella genus (all rho ≤ -0.24, p ≤ 0.023). In participants with high lipopolysaccharide values, the plasma levels of AEA and related N-acylethanolamines, as well as AA and 2-AG, were negatively correlated with plasma levels of lipopolysaccharide (all rho ≤ -0.24, p ≤ 0.020). Plasma levels of endocannabinoids and their analogues are correlated to specific fecal bacterial genera involved in maintaining gut barrier integrity in young adults. This suggests that plasma levels of endocannabinoids and their analogues may play a role in the gut barrier integrity in young adults.
PB MDPI
YR 2022
FD 2022-05-18
LK http://hdl.handle.net/10668/21479
UL http://hdl.handle.net/10668/21479
LA en
NO Ortiz-Alvarez L, Xu H, Di X, Kohler I, Osuna-Prieto FJ, Acosta FM, et al. Plasma Levels of Endocannabinoids and Their Analogues Are Related to Specific Fecal Bacterial Genera in Young Adults: Role in Gut Barrier Integrity. Nutrients. 2022 May 20;14(10):2143
DS RISalud
RD Apr 9, 2025