RT Journal Article
T1 Bronchopulmonary infection-colonization patterns in Spanish cystic fibrosis patients: Results from a national multicenter study
A1 de-Dios-Caballero, Juan
A1 del-Campo, Rosa
A1 Royuela, Ana
A1 Sole, Amparo
A1 Maiz, Luis
A1 Olveira, Casilda
A1 Quintana-Gallego, Esther
A1 de-Gracia, Javier
A1 Cobo, Marta
A1 Gomez-de-la-Pedrosa, Elia
A1 Oliver, Antonio
A1 Canton, Rafael
A1 Sole, Amparo
A1 Cortell, Isidoro
A1 Asensio, Oscar
A1 Garcia, Gloria
A1 Martinez, Maria Teresa
A1 Cols, Maria
A1 Salcedo, Antonio
A1 Vazquez, Carlos
A1 Baranda, Felix
A1 Giron, Rosa
A1 Quintana, Esther
A1 Delgado, Isabel
A1 de-Miguel, Maria Angeles
A1 Garcia, Marta
A1 Oliva, Concepcion
A1 Prados, Maria Concepcion
A1 Barrio, Maria Isabel
A1 Pastor, Maria Dolores
A1 Olveira, Casilda
A1 de-Gracia, Javier
A1 Alvarez, Antonio
A1 Escribano, Amparo
A1 Castillo, Silvia
A1 Figuerola, Joan
A1 Togores, Bernat
A1 Oliver, Antonio
A1 Lopez, Carla
A1 de-Dios-Caballero, Juan
A1 Tato, Marta
A1 Maiz, Luis
A1 Suarez, Lucrecia
A1 Canton, Rafael
K1 Cystic fibrosis
K1 Pulmonary infection-colonization
K1 Respiratory pathogens
K1 P. aeruginosa
K1 Resistant staphylococcus-aureus
K1 Antimicrobial susceptibility
K1 Spain
K1 Epidemiology
K1 Microbiology
K1 Prevention
AB Background: Clinical and demographical knowledge on Spanish cystic fibrosis (CF) patients is incomplete as no national registry exists. CF-microbiology has not been studied at national level. The results of the first Spanish multicenter study on CF microbiology are presented.Methods: 24 CF-Units for adult (n = 12) and pediatric (n = 12) patients from 17 hospitals provided sputa and clinical data from 15 consecutive patients. Cultures and susceptibility testing were performed. Colonization impact on pulmonary function was assessed.Results: 341 patients [mean (SD) age 21 (11) years, 180 >= 18 years, mean (SD) FEV1 = 68 (25)%] were included. Pseudomonas aeruginosa was reported as chronic, intermittent or absent in 46%, 22% and 32% of patients, respectively. The annual prevalence was 62%. Positive P. aeruginosa and methicillin-resistant Staphylococcus aureus cultures were significantly associated with lower FEV1 (p = 18 years, mean (SD) FEV1 = 68 (25)%] were included. Pseudomonas aeruginosa was reported as chronic, intermittent or absent in 46%, 22% and 32% of patients, respectively. The annual prevalence was 62%. Positive P. aeruginosa and methicillin-resistant Staphylococcus aureus cultures were significantly associated with lower FEV1 (pb 0.001 and p = 0.003, respectively). Conclusions: The representative subset of the Spanish CF-population which has been clinically, demographically and microbiologically characterized will serve as a reference for future CF studies in Spain.
PB Elsevier 
SN 1569-1993
YR 2015
FD 2015-09-28
LK http://hdl.handle.net/10668/18811
UL http://hdl.handle.net/10668/18811
LA en
NO Research at the Microbiology Departments of Ramón y Cajal (Madrid, Spain) and Son Espases (Palma de Mallorca, Spain) University Hospitals in the field of CF are funded by the Plan Nacional de I+D+i 2008–2011, Instituto de Salud Carlos III of Spain (research grants PI12/00734 and PI12/00103) and cofinanced by the European Development Regional Fund (A Way to Achieve Europe program; Spanish Network for Research in Infectious Diseases grant REIPI RD12/0015).
DS RISalud
RD Apr 5, 2025