%0 Journal Article
%A de-Dios-Caballero, Juan
%A del-Campo, Rosa
%A Royuela, Ana
%A Sole, Amparo
%A Maiz, Luis
%A Olveira, Casilda
%A Quintana-Gallego, Esther
%A de-Gracia, Javier
%A Cobo, Marta
%A Gomez-de-la-Pedrosa, Elia 
%A Oliver, Antonio
%A Canton, Rafael
%A Sole, Amparo
%A Cortell, Isidoro
%A Asensio, Oscar
%A Garcia, Gloria
%A Martinez, Maria Teresa
%A Cols, Maria
%A Salcedo, Antonio
%A Vazquez, Carlos
%A Baranda, Felix
%A Giron, Rosa
%A Quintana, Esther
%A Delgado, Isabel
%A de-Miguel, Maria Angeles
%A Garcia, Marta
%A Oliva, Concepcion
%A Prados, Maria Concepcion 
%A Barrio, Maria Isabel
%A Pastor, Maria Dolores
%A Olveira, Casilda
%A de-Gracia, Javier
%A Alvarez, Antonio
%A Escribano, Amparo
%A Castillo, Silvia
%A Figuerola, Joan
%A Togores, Bernat
%A Oliver, Antonio
%A Lopez, Carla
%A de-Dios-Caballero, Juan
%A Tato, Marta
%A Maiz, Luis
%A Suarez, Lucrecia
%A Canton, Rafael
%T Bronchopulmonary infection-colonization patterns in Spanish cystic fibrosis patients: Results from a national multicenter study
%D 2015
%@ 1569-1993
%U http://hdl.handle.net/10668/18811
%X Background: Clinical and demographical knowledge on Spanish cystic fibrosis (CF) patients is incomplete as no national registry exists. CF-microbiology has not been studied at national level. The results of the first Spanish multicenter study on CF microbiology are presented.Methods: 24 CF-Units for adult (n = 12) and pediatric (n = 12) patients from 17 hospitals provided sputa and clinical data from 15 consecutive patients. Cultures and susceptibility testing were performed. Colonization impact on pulmonary function was assessed.Results: 341 patients [mean (SD) age 21 (11) years, 180 >= 18 years, mean (SD) FEV1 = 68 (25)%] were included. Pseudomonas aeruginosa was reported as chronic, intermittent or absent in 46%, 22% and 32% of patients, respectively. The annual prevalence was 62%. Positive P. aeruginosa and methicillin-resistant Staphylococcus aureus cultures were significantly associated with lower FEV1 (p = 18 years, mean (SD) FEV1 = 68 (25)%] were included. Pseudomonas aeruginosa was reported as chronic, intermittent or absent in 46%, 22% and 32% of patients, respectively. The annual prevalence was 62%. Positive P. aeruginosa and methicillin-resistant Staphylococcus aureus cultures were significantly associated with lower FEV1 (pb 0.001 and p = 0.003, respectively). Conclusions: The representative subset of the Spanish CF-population which has been clinically, demographically and microbiologically characterized will serve as a reference for future CF studies in Spain.
%K Cystic fibrosis
%K Pulmonary infection-colonization
%K Respiratory pathogens
%K P. aeruginosa
%K Resistant staphylococcus-aureus
%K Antimicrobial susceptibility
%K Spain
%K Epidemiology
%K Microbiology
%K Prevention
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