RT Journal Article
T1 Antibody responses to flagellin C and Streptococcus gallolyticus pilus proteins in colorectal cancer.
A1 Butt, Julia
A1 Fernández de Larrea, Nerea
A1 Tjalsma, Harold
A1 Roelofs, Rian
A1 Kato, Ikuko
A1 Martín, Vicente
A1 Pérez-Gómez, Beatriz
A1 Moreno, Victor
A1 Dierssen-Sotos, Trinidad
A1 Castilla, Jesús
A1 Fernández-Tardón, Guillermo
A1 Amiano, Pilar
A1 Salas, Dolores
A1 Alguacil, Juan
A1 Jiménez-Moleón, José Juan
A1 Huerta, José María
A1 de Sanjosé, Silvia
A1 Del Campo, Rosa
A1 Kogevinas, Manolis
A1 Pollán, Marina
A1 Pawlita, Michael
A1 Waterboer, Tim
A1 Boleij, Annemarie
A1 Aragonés, Nuria
AB Antibodies to Streptococcus gallolyticus subspecies gallolyticus (SGG) have been associated with colorectal cancer (CRC). Because SGG may correlate with impaired gut epithelia, we assessed the association of antibodies to bacterial flagellin C (FliC), a measure potentially related to this impairment, with CRC and the CRC-specific interaction with antibodies to SGG proteins. Antibodies to FliC and SGG pilus proteins Gallo2178 and Gallo2179 were measured in two independent studies, a combined study from Nijmegen and Detroit (93 CRC cases, 74 controls) and a replication data set including 576 cases and 576 controls from the Spanish multicenter multicase-control study (MCC-Spain). Logistic regression was applied to assess whether antibodies to FliC were associated with CRC and modified the association of antibodies to SGG proteins with CRC. Antibodies to FliC were associated with those to SGG Gallo2178 among CRC cases, resulting in an interaction in the association of antibodies to Gallo2178 with CRC (p = 0.007). This association was only present among individuals with high antibody responses to FliC (OR: 2.42, 95% CI: 1.45-4.06). In conclusion, our findings suggest that colorectal tumorigenesis could be accompanied by an impaired integrity of the epithelium that could result in associated increased antibody responses to bacterial proteins.
YR 2019
FD 2019-07-26
LK http://hdl.handle.net/10668/14318
UL http://hdl.handle.net/10668/14318
LA en
DS RISalud
RD Apr 8, 2025