RT Journal Article
T1 Hemodialysis patients receiving a greater Kt dose than recommended have reduced mortality and hospitalization risk
A1 Maduell, Francisco
A1 Ramos, Rosa
A1 Varas, Javier
A1 Martin-Malo, Alejandro
A1 Molina, Manuel
A1 Perez-Garcia, Rafael
A1 Marcelli, Daniele
A1 Moreso, Francesc
A1 Aljama, Pedro
A1 Ignacio Merello, Jose
K1 adequacy
K1 hospitalization
K1 ionic dialysance
K1 Kt
K1 survival
K1 Body-surface area
K1 Ionic dialysance
K1 Hemodiafiltration
K1 Size
K1 Clearance
K1 Adequacy
K1 Gender
K1 Women
K1 Men
AB Achieving an adequate dialysis dose is one of the key goals for dialysis treatments. Here we assessed whether patients receiving the current cleared plasma volume (Kt), individualized for body surface area per recommendations, had improved survival and reduced hospitalizations at 2 years of follow-up. Additionally, we assessed whether patients receiving a greater dose gained more benefit. This prospective, observational, multicenter study included 6129 patients in 65 Fresenius Medical Care Spanish facilities. Patients were classified monthly into 1 of 10 risk groups based on the difference between achieved and target Kt. Patient groups with a more negative relationship were significantly older with a higher percentage of diabetes mellitus and catheter access. Treatment dialysis time, effective blood flow, and percentage of on-line hemodiafiltration were significantly higher in groups with a higher dose. The mortality risk profile showed a progressive increase when achieved minus target Kt became more negative but was significantly lower in the group with 1 to 3 L clearance above target Kt and in groups with greater increases above target Kt. Additionally, hospitalization risk appeared significantly reduced in groups receiving 9 L or more above the minimum target. Thus, prescribing an additional 3 L or more above the minimum Kt dose could potentially reduce mortality risk, and 9 L or more reduce hospitalization risk. As such, future prospective studies are required to confirm these dose effect findings.
PB Nature publishing group
SN 0085-2538
YR 2016
FD 2016-12-01
LK http://hdl.handle.net/10668/18832
UL http://hdl.handle.net/10668/18832
LA en
DS RISalud
RD Apr 10, 2025