RT Journal Article
T1 Development of Biotransamination Reactions towards the 3,4-Dihydro-2H-1,5-benzoxathiepin-3-amine Enantiomers
A1 Gonzalez-Martinez, Daniel
A1 Fernandez-Saez, Nerea
A1 Cativiela, Carlos
A1 Campos, Joaquin M.
A1 Gotor-Fernandez, Vicente
K1 amine transaminases
K1 asymmetric synthesis
K1 benzoxathiepins
K1 biocatalysis
K1 biotransamination
K1 stereoselective synthesis
K1 Efficient asymmetric-synthesis
K1 Employing omega-transaminases
K1 Optically-active amines
K1 Imine reductases ireds
K1 Chiral amines
K1 1,5-benzoxathiepin derivatives
K1 Amination
K1 Biocatalysis
K1 Ketones
K1 Reactivity
AB The stereoselective synthesis of chiral amines is an appealing task nowadays. In this context, biocatalysis plays a crucial role due to the straightforward conversion of prochiral and racemic ketones into enantiopure amines by means of a series of enzyme classes such as amine dehydrogenases, imine reductases, reductive aminases and amine transaminases. In particular, the stereoselective synthesis of 1,5-benzoxathiepin-3-amines have attracted particular attention since they possess remarkable biological profiles; however, their access through biocatalytic methods is unexplored. Amine transaminases are applied herein in the biotransamination of 3,4-dihydro-2H-1,5-benzoxathiepin-3-one, finding suitable enzymes for accessing both target amine enantiomers in high conversion and enantiomeric excess values. Biotransamination experiments have been analysed, trying to optimise the reaction conditions in terms of enzyme loading, temperature and reaction times.
PB Mdpi
SN 2073-4344
YR 2018
FD 2018-10-01
LK http://hdl.handle.net/10668/19253
UL http://hdl.handle.net/10668/19253
LA en
DS RISalud
RD Apr 9, 2025