RT Journal Article
T1 Preoperative chemoradiotherapy for rectal cancer: the sensitizer role of the association between miR-375 and c-Myc.
A1 Conde-Muiño, Raquel
A1 Cano, Carlos
A1 Sánchez-Martín, Victoria
A1 Herrera, Antonio
A1 Comino, Ana
A1 Medina, Pedro P
A1 Palma, Pablo
A1 Cuadros, Marta
K1 c-Myc
K1 chemoradiotherapy-resistance
K1 miRNAs
K1 rectal cancer
K1 regulatory networks
AB Administration of chemoradiation before tumor resection has revolutionized the management of locally advanced rectal cancer, but many patients have proven resistant to this preoperative therapy. Our group recently reported a negative correlation between c-Myc gene expression and this resistance. In the present study, integrated analysis of miRNA and mRNA expression profiles was conducted in 45 pre-treatment rectal tumors in order to analyze the expressions of miRNAs and c-Myc and their relationship with clinicopathological factors and patient survival. Twelve miRNAs were found to be differentially expressed by responders and non-responders to the chemoradiation. Functional classification revealed an association between the differentially expressed miRNAs and c-Myc. Quantitative real-time PCR results showed that miRNA-148 and miRNA-375 levels were both significantly lower in responders than in non-responders. Notably, a significant negative correlation was found between miRNA-375 expression and c-Myc expression. According to these findings, miRNA-375 and its targeted c-Myc may be useful as a predictive biomarker of the response to neoadjuvant treatment in patients with locally advanced rectal cancer.
YR 2017
FD 2017-07-19
LK https://hdl.handle.net/10668/25135
UL https://hdl.handle.net/10668/25135
LA en
DS RISalud
RD Apr 6, 2025